当归补血汤对辐射损伤小鼠免疫功能的影响  

Effect of Danggui Buxue Decoction(当归补血汤) on Immune Function in Mice with Radiation Injury

作　　者：冯璟[1] 于远望[1] 

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《中医药导报》2016年第13期17-20,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:观察当归补血汤对辐射损伤小鼠免疫功能的影响。方法:将实验小鼠随机分为5组(正常对照组、模型组、当归补血汤低、中、高剂量组),采用60Co-γ放射源照射实验小鼠建立辐射损伤模型,观察小鼠的一般情况,测定各组小鼠的外周血淋巴细胞数、分析血清T淋巴细胞亚群、计数脾脏集落形成数目(CFU-S)并计算免疫器官脏器指数。结果:受60Co-γ射线照射的小鼠外周血淋巴细胞数、血清T淋巴细胞亚群、脾脏指数及胸腺指数均明显降低,脾脏集落形成数目增多,当归补血汤可使各组小鼠免疫功能参数均提高,促进免疫功能损伤的恢复。结论:当归补血汤对辐射小鼠免疫系统的损伤有保护和促进修复作用,且与剂量相关。Objective： To observe the effect of Danggui Buxue Decoction on immune function in mice with radiation injury. Methods： The mice were randomly divided into 5 groups （normal control group, model group, Danggui Buxue Decoction, in low, middle and high dose group）. The radiation damage model was established by 60Co-γ,irradiation in mice, and the general condition of mice was observed. The number of peripheral blood lymphocytes was determined in mice. The serum T lymphocyte subsets were analyzed. The number of colony formation （CFU-S） was counted and the index of immune organs was calculated. Results： The number of pe- ripheral blood lymphocytes, the serum T-lymphocyte subsets, spleen index and thymus index were significantly decreased in mice irradiated by 6~Co-~/ray. And the number of colony formation in the spleen increased. Dang- gui Buxue Decoction can improve immune function parameters and promote the recovery of immune function in- jury in mice with radiation injury. Conclusions： Danggui Buxue Decoction can protect and repair function dam- age of immune system in irradiated mice, which is related to dose.

关 键 词：当归补血汤 辐射损伤 免疫 小鼠 

分 类 号：R285.5[医药卫生—中药学]