Wnt/β-catenin信号介导脐带间充质干细胞修复糖尿病创面的应用前景  

Application prospect of umbilical cord mesenchymal stem cells mediated by Wnt/β-catenin signaling for repair of diabetic wounds

作　　者：邱虹 韩焱福[2] 陶然[3] 

机构地区：[1]解放军海军机关门诊部口腔科,北京100036 [2]首都医科大学附属北京世纪坛医院整形外科,100038 [3]解放军总医院整形修复外科,北京100853

出　　处：《中华损伤与修复杂志（电子版）》2016年第2期144-146,共3页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：北京市科技新星计划项目(Z1511000003150128)

摘　　要：糖尿病并发创面致病机制复杂,缺乏有效治疗措施。间充质干细胞(MSC)具有促进创面愈合的作用,与骨髓MSC比较,脐带来源的MSC生物学特性优势明显。Wnt是干细胞转归和皮肤再生的强效调节信号分子,而糖尿病创面Wnt信号通路功能低下。Wnt/β-catenin信号介导脐带MSC修复糖尿病创面有潜在的临床应用前景,本文综述了这方面的研究现状及存在问题。The pathogenesis of diabetes wounds is complicate, and there lacks effective treatment strategies. Mesenchymal stem cells can promote wound healing. Compared with bone marrow mesenchymal stem cells, umbilical cord mesenchymal stem ceils have obvious advantages in biological property. Wnt is potent regulatory molecules for stem cell turnover and skin regeneration, while the function of Wnt signaling pathway in diabetic wound is low. Umbilical cord mesenchymal stem cells mediated by Wnt/β-catenin signaling have some application potential in the repair of diabetic wounds. In this paper, the authors summarize the current situation and existing problems in this field.

关 键 词：间质干细胞 糖尿病 伤口愈合 WNT信号通路 

分 类 号：R587.2[医药卫生—内分泌]