锁阳治疗前列腺增生的研究现状  

Research progress of effects of Cynomorium songaricum Rupr. on the benign prostatic hyperplasia treatment

作　　者：陶蕊[1] 苗琳[1] 王雪妮[1] WICHAI Nuttapong 

机构地区：[1]天津中医药大学中医药研究院,天津300193

出　　处：《中国临床药理学杂志》2016年第12期1150-1152,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金青年科子基金资助项目(81303293);天津市应用基础与前沿技术研究计划(青年项目)基金资助项目(14JCQNJC13400)

摘　　要：前列腺增生症(BPH)属中老年男性泌尿外科的常见疾病。患者不具备手术指征的较多,因此药物成为治疗BPH的首选。中药锁阳为补肾壮阳的常用药,临床上用于BPH的治疗。锁阳具有调节肾功能、缓解肾阳虚、抗氧化、抗应激、抗疲劳以及激素样等方面作用;其含有黄酮类、三萜类、多糖类等多种活性成分。但其作用机制和药效物质基础尚不十分明确。为此本文综述了锁阳及其活性成分与治疗BPH相关的药理作用。Benign prostatic hyperplasia （BPH） is a common disease of the urinary surgery in eider men. Because of the age, most patients choose medication as the main treatment instead of operation. The tradi- tional Chinese medicine Cynomorium songaricum Rupr. has been consi- dered as a typical medicine for invigorating the kidney and strengthening Yang, and thus it is widely used for BPH treatment, while the active constituents and mechanism involved remain unclear. Pharmacological studies showed that Cynomorium songaricum Rupr. had the effects on regulating the renal functions, relieving kidney -yang deficiency, anti - oxidant, anti- stress, anti- fatigue and hormone -like effect. It con- tains a variety of active constituents including flavonoid, triterpenes, polysaccharides and so forth. Here, in this review, we summarized the pharmacological effects and the constituents of Cynomorium songaricum Rupr. which may be related with BPH and further discussed the possible active constituents that may play important roles in BPH treatment.

关 键 词：锁阳 良性前列腺增生 雌激素活性 雄激素活性 熊果酸 

分 类 号：R28[医药卫生—中药学]