MicroRNAs对羊生长发育调控作用的研究进展  

Research progress on MicroRNAs in regulating the growth and development of goat and sheep

作　　者：林月霞[1] 吕玉华[1] 丁宏林[1] 廖荣荣[1] 

机构地区：[1]上海市农业科学院畜牧兽医研究所,上海201106

出　　处：《上海农业学报》2016年第3期172-176,共5页Acta Agriculturae Shanghai

基　　金：上海市科技兴农推广项目[沪农科推字(2014)第3-1号];上海市科委项目(15391912901)

摘　　要：MicroRNAs(miRNAs)是一类高度保守的、在转录后水平调控基因表达的非编码小RNA分子,miRNAs通过与靶基因的3'端非翻译区的互补序列结合,抑制靶基因的翻译,进而调控一系列的生理生化过程,主要包括机体细胞的增殖、分化、凋亡、信号转导、肿瘤形成等。文章综述了miRNAs的合成与功能,尤其是近年来miRNAs在羊的皮毛生长、肌肉生长以及卵巢发育等生长发育过程中的研究进展与应用。MicroRNAs（miRNAs） are important regulators in biology.MiRNAs are a class of small noncoding RNAs that target mRNAs for translational repression or degradation.MiRNAs target mRNAs by base-pairing with the 3＇-untranslated regions（3 ＇-UTRs） of mRNAs.MiRNAs have been shown to play roles in many biological processes,including cell proliferation,differentiation,apoptosis,signal transduction and ontogenesis.The paper summarizes the identification,expression,and function of miRNAs in two important farm animal species;goat and sheep,highlights the potential role of miRNAs in regulating economically important traits,such as skin,hair,muscle and ovary.

关 键 词：MICRORNAS 山羊 绵羊 生长 调控 

分 类 号：S826[农业科学—畜牧学]