白念珠菌细胞内钙离子稳态和钙离子/钙调磷酸酯酶信号途径的调控机理研究进展  

Progress in the Mechanisms Regulating Calcium Homeostasis and Calcium/Calcineurin Signaling in Candida albicans

作　　者：徐大勇[1,2] 蒋伶活[1] 

机构地区：[1]江南大学生物工程学院粮食发酵工艺与技术国家工程实验室,无锡214122 [2]淮北师范大学生命科学学院,淮北235000

出　　处：《中国细胞生物学学报》2016年第5期633-639,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81371784;81571966)资助的课题~~

摘　　要：钙离子稳态和钙离子/钙调磷酸酯酶信号途径在真核细胞中高度保守。与最简单的模式真核生物(酿酒酵母菌)一样,人体病原真菌白念珠菌的细胞中存在各种钙通道、钙泵和钙交换器以及完整的钙离子/钙调磷酸酯酶信号途径成员,它们在维持白念珠菌胞内钙离子稳态以及应答外界环境压力、耐药性、形态发生和致病性等方面有着至关重要的作用。对白念珠菌钙离子稳态和钙离子/钙调磷酸酯酶信号途径调控机理的认知,有助于了解其致病过程和耐药机理,同时可以为发现和开发新的抗真菌药物提供研究基础。该文结合所在实验室相关研究工作对这一领域的最新研究进展作了综述。Calcium homeostasis and Ca2＋/calcineurin signaling pathway are highly conserved in eukaryotic cells. Like the simplest eukaryotic model organism, Saccharomyces cerevisiae, the human fimgal pathogen Candida albicans has calcium channels, pumps and Ca2＋/H＋ exhangers as well as components of the Ca2＋/calcineurin signaling, which play a vital role in maintaining the cytosolic calcium homeostasis and regulating the response to environmental stresses, the drug tolerance and the morphogenesis and virulence. Understanding mechanisms regulating calcium homeostasis and the Ca2＋/calcineurin signaling would help us to elucidate the pathogenesis and drug tolerance of C. albicans, and facilitate the discovery and development of new anti-fungal drugs. Here, based on our research work, we briefly summarize recent progress in this area of research.

关 键 词：白念珠菌 钙离子 钙离子稳态 信号途径 

分 类 号：R379.4[医药卫生—病原生物学]