移植无原核胚胎出生健康子代  

Live births resulting from “unfertilized” embryos

作　　者：刘景[1] 李真[1] 郭良慧[1] 孙丽君[1] 郝大勇[1] 张建瑞[1] 王兴玲[1] 

机构地区：[1]郑州大学第三附属医院生殖医学中心,郑州450052

出　　处：《生殖与避孕》2016年第6期479-483,共5页Reproduction and Contraception

摘　　要：目的:观察无原核(PN)胚胎的发生率、影响因素及移植0PN胚胎周期的临床治疗结局。方法:回顾性分析4 424个IVF-ET周期移植0PN来源胚胎的结局。结果:0PN胚胎的发生率为11.3%。女方的年龄、获卵数及优质胚胎率与0PN的发生率相关。70个周期移植了112个0PN来源的卵裂期胚胎,获得的临床妊娠率为24.3%(17/70),植入率为17.0%(19/112),流产率为11.8%(2/17)。1例死产。13个周期活产13个健康子代,未见畸形的发生。对0PN来源的囊胚进行复苏周期移植,可获得与2PN囊胚相似的临床妊娠率及植入率,但流产率较高,差异有统计学意义。结论:IVF周期中,含有0PN优质胚胎的周期可能有较好的临床治疗结局。形态正常的0PN胚胎有较好的胚胎发育潜能,在无2PN胚胎的情况下,可考虑移植0PN来源胚胎。Objective： To investigate the incidence and influence factors of embryos derived from ＂unfertilized oocytes＂, i.e. oocytes do not displaying pronuclei （PN） at the time of the fertilization check, and the clinical pregnancy outcomes when transferring OPN embryos. Methods： In this retrospective study, 4 424 IVF- ET cycles were reviewed and the outcome of transferring OPN embryos was analyzed. Results： The occurence rate of OPN embryos was 11.3% （4 966/43 949）. The female age, the number of oocytes and the top-quality embryo rate were significantly correlated with OPN embryo occurence. Totally 112 OPN embryos were transferred in 70 cycles. The implantation rate of the cycles when OPN embryos were exclusively transferred was 17.0% with 2 miscarriages and 1 stillbirth observed. Of the 13 healthy infants born from 13 cycles, there were no reports of deformities. OPN derived blastocyst can obtain similar clinical pregnancy rate and implantation rate as those of 2PN blastocyst, but the rate of abortion was higher, with a significant difference. Conclusion： The appearance of 0PN embryos in IVF can be considered as an indicator of a cycle with appropriate embryo development. Trans- ferring 0PN embryos should be taken into account when alternative embryos for transferring are not available.

关 键 词：异常受精 原核(PN) 妊娠 

分 类 号：R714.8[医药卫生—妇产科学]