外泌体在子痫前期发病机理中的研究进展  

Research advances of exosome in the pathogenesis of preeclampsia

作　　者：贾林燕[1] 周倩[1] 王凯[1] 

机构地区：[1]同济大学附属第一妇婴保健院转化医学研究中心,上海200040

出　　处：《生殖与避孕》2016年第6期506-510,共5页Reproduction and Contraception

摘　　要：外泌体(exosome)是由多种细胞分泌的膜性纳米囊泡,携带蛋白、m RNA、mi RNA和脂质等内含物,通过靶细胞传递内含物,介导细胞与细胞之间的通讯。孕妇血浆中由胎盘释放的外泌体浓度是未孕女性的50倍,子痫前期患者体内外泌体的蛋白和mi RNA的表达水平发生了变化,使母体滋养细胞侵袭能力不足、降低内皮细胞的功能和血管生成能力,导致子痫前期等病理性妊娠。所以孕妇血浆中外泌体表达谱的改变可应用于胎盘功能紊乱的临床诊断。Exosomes are nanometric membrane vesicles secreted by various cell types, which are enriched in inclusions, such as proteins, mRNA, miRNA, lipids, and so on. Exosomes mediate cell-cell commu- nication via transferring the inclusions to the target cells. The placenta-derived exosome concentration in the plasma of pregnant group is 50 times more than that of non-pregnant group. The expression levels of exosomal proteins and miRNA in preeclampsia patients have changed, resulting in the limited invasion ability of maternal trophoblast cells, decline of endothelial cell function and angiogenesis ability, and further causing pathological pregnancy of preeclampsia. Therefore, the expression changes of plasma exosomes can be used for clinical diagnosis of placental function disorder.

关 键 词：外泌体(exosome) 子痫前期:miRNA 

分 类 号：R714.244[医药卫生—妇产科学]