3.0T动态对比增强磁共振与直肠癌组织分化程度关系的探讨  

Explore the Relationship Between 3.0T Dynamic Contrast-Enhanced Magnetic Resonance and Tissue Differentiation Degree of Rectal Cancer

作　　者：朱丽娜[1] 张曦[1] 颜社平[2] 刘艳[1] 黎星[1] 赵志伟[1] 明洁[1] 王慧丽[1] 杨爱梅[1] 

机构地区：[1]新疆医科大学附属肿瘤医院核磁室,830011 [2]兰州军区乌鲁木齐总医院超声科,830000

出　　处：《现代医用影像学》2016年第2期292-294,共3页Modern Medical Imageology

基　　金：新疆医科大学附属肿瘤医院科研启动基金项目(肿2014-15)项目名称:磁共振扩散加权成像早期评估直肠癌新辅助治疗疗效;新疆医科大学附属肿瘤医院新技术项目:3.0T高分辨磁共振成像对直肠癌进行术前分期及疗效评估

摘　　要：目的:利用3.0T动态对比增强磁共振(dynamic contrast-enhanced magnetic resonance,DCE-MR),探讨直肠癌患者容量转移常数(volume transfer constant,Ktrans)、速率常数(rate constant,Kep)以及细胞外血管外间隙容积比(extra-vascular extra-cellular space fractional volume,Ve)与肿瘤组织分化程度的关系。材料与方法:根据术后病理,56例直肠癌患者分为高、中、低分化组,利用单因素方差分析比较各组Ktrans、Kep、Ve值。结果:高、中、低分化组的Ktrans值分别为0.154±0.009/min、0.210±0.027/min、0.365±0.021/min;Kep值分别为0.469±0.008/min、0.528±0.080/min、0.637±0.006/min;Ve值分别为0.739±0.006、0.841±0.070、0.923±0.105,高、中、低分化组间Ktrans、Kep、Ve差异均有统计学意义(P<0.01)。结论:DCE-MR定量参数Ktrans、Kep、Ve值可提供肿瘤微循环信息,并且能够无创性预测直肠癌的恶性程度。Purpose： To explore the relationship between Ktrans, Kep, Ve and tissue differentiation degree of rectal cancer by use 3.0T dynamic contrast-enhanced MR（DCE-MR）. Materials and Methods： 56 rectal cancer patients were di- vided into well, moderately and poorly differentiated group according to postoperative pathology. Contrasting Ktrans, Kep, Ve of each group by single factor variance analysis. Results： Ktrans of well, moderately and poorly differentiated group was 0. 154 ±0. 009/min, 0. 210 ±0. 027/min, 0. 365 ±0. 021/min; Kep was 0. 469 ±0. 008/min, 0. 528 ±0. 080/rain, 0. 637 ± 0. 006/min; Ve was 0. 739 ±0. 006, 0. 841±0. 070, 0. 923 ± 0. 105, differences of Ktrans, Kep, Ve of well, moderately and poorly differentiated group were statistically significant （P 〈 0. 01 ）. Conclusion： Ktrans, Kep, Ve of DCE-MR quantita- tive parameters can provide information of tumor microcirculation, and predict noninvasively malignant degree of rectal cancer.

关 键 词：直肠癌 组织分化程度 动态对比增强磁共振. 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.37[医药卫生—诊断学]