老年人高密度脂蛋白与高敏肌钙蛋白T的关系  

Relationship between high-density lipoprotein and high-sensitivity cardial troponin T in elderly

作　　者：刘源[1] 肖文凯[1] 高萌[1] 付士辉[2] 王浩[1] 李冬云[1] 骆雷鸣[1] 白永怿[1] 叶平[1] 

机构地区：[1]解放军总医院南楼心血管内科,北京100853 [2]解放军总医院海南分院心内科,海南省三亚572013

出　　处：《中华急诊医学杂志》2016年第6期797-801,共5页Chinese Journal of Emergency Medicine

基　　金：北京市科技新星资助项目（Z121107002513124）;国家重点基础研究发展计划（973计划）（2013CB530804）

摘　　要：目的高密度脂蛋白胆固醇（HDL—C）对心血管系统具有保护作用，且低水平的HDL—C是独立于低密度脂蛋白胆固醇之外的心血管危险因素。高敏肌钙蛋白T（hs—cTnT）不仅是首选的心肌损伤标志物，也是心血管不良预后有效的预测因子。国内外鲜有研究在社区老年人群中探讨HDL—C和hs—cTnT水平之间的关系。方法在885例中国社区老年人群中对HDL—C与hs—cTnT水平之间的关系进行单因素分析及多元线性回归分析。结果研究人群中共有367例男性（41．5％）和518例女性（58．5％），年龄范围为60～96岁，（69．2±6．3）岁。简单相关分析的结果表明，HDL-C与hs—cTnT水平呈负相关关系（r=43．06，P=0．008）。在校正混杂因素后，社区老年人群的hs-cTnT水平与HDL—C水平的所有四分位数组呈独立相关性。结论在中国社区老年人群中发现HDL—C水平与心肌损伤独立相关。Objective To High-density lipoprotein cholesterol （HDL-C） has the protective effect on cardiovascular system and low levels of HDL-C are considered as risk factors of cardiovascular diseases independent of low-density lipoprotein cholesterol. High-sensitivity eardial troponin T （hs-eTnT） was preferred marker of myocardial damage and predictor of cardiovascular outcomes. There was nearly no study exploring the relationship between HDL-C and hs-cTnT levels in community elderly. Methods To evaluate the correlation between HDL-C and hs-cTnT levels in a Chinese community population of 885 elderly, univariate analyses and muhivariable linear regression analysis were performed. Results There were 367 males （41.5%） and 518 females （58.5%） in all. Their age ranged form 60 to 96 years, with a mean age of （69. 2 -＋ 6. 36） years. In univariate analyses, HDL-C levels were negatively related to hs-cTnT levels （ r = - 0. 06, P = 0. 008 ） . After adjustment for some confounding factors, hs-cTnT levels were independently associated with different groups of HDL-C levels divided by the quartiles in community elderly. Conclusions In Chinese community elderly, we found that HDL-C levels have the independent associations with myocardial damage.

关 键 词：高密度脂蛋白胆固醇 高敏肌钙蛋白T 老年人 心血管系统 多因素分析 关系 

分 类 号：R54[医药卫生—心血管疾病]