Hedgehog信号通路参与肿瘤耐药机制研究的最新进展  

Advances of Hedgehog pathway in tumor resistance

作　　者：黄少良[1,2] 赵丽[1,2] 郭青龙[1,2] 吴玉林[3] 

机构地区：[1]中国药科大学江苏省肿瘤发生与干预重点实验室,南京210009 [2]中国药科大学天然药物活性组分与药效国家重点实验室,南京210009 [3]中国药科大学生理学教研室,南京210009

出　　处：《中国药科大学学报》2016年第3期259-266,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81473231);江苏省自然科学基金资助项目(No.BK20150028)~~

摘　　要：Hedgehog信号通路调控肿瘤增殖、周期调控、侵袭转移等生理过程,维持着肿瘤的发生与发展。研究发现Hedgehog信号通路在多种耐药肿瘤的异常激活,进一步研究证实该通路通过激活靶基因以及与其他通路相互作用等方式介导了肿瘤耐药。因此,Hedgehog信号通路已然成为逆转肿瘤耐药的重要靶点。本文就Hedgehog信号通路传导途径及近年来在肿瘤耐药机制研究中的现状作一综述。Hedgehog pathway regulates the physiological process of tumor cells, including proliferation, cycle, invasion and metastasis, and maintains tumorigenesis and development. With abnomal activation of Hedgehog pathway, most tumors response poorly to chemotherapy, which is mediated by Hedgehog pathway through activation of target gene and crosstalk with other pathways. Herein, Hedgehog pathway has been an important target for reversing resistance. In this study, the Hedgehog pathway and role of Hedgehog-mediated resistance in recent years are reviewed.

关 键 词：HEDGEHOG信号通路 肿瘤耐药 靶点 进展 

分 类 号：R96[医药卫生—药理学]