Let-7家族与肺部疾病研究进展  

Research Progression of Let-7 and Pulmonary Diseases

作　　者：罗妍妍[1] 吴升华[1] 陈筱青[1] 

机构地区：[1]南京医科大学第一附属医院,江苏省南京市210029

出　　处：《中国全科医学》2016年第17期1998-2001,共4页Chinese General Practice

基　　金：国家自然科学基金资助项目(81300521)

摘　　要：MicroRNA(miRNA)是一类内源性、广泛分布的非编码RNA,这些非编码RNA通过调控基因表达的方式参与生命活动的一系列重要的过程,包括细胞增殖、凋亡、分化、个体发育等。Let-7家族是继Lin-4之后于2000年发现的第二个miRNA家族,目前认为Let-7家族与肿瘤、心血管疾病、病毒感染等发生发展有关,尤其是与肺部疾病关系密切。本文将针对Let-7家族与肺部疾病(肺癌、肺发育不良、肺损伤、特发性肺纤维化、肺部炎症)的研究进展进行综述。MicroRNA（ miRNA） is a class of endogenous non coding RNA and is widely distributed. It involves a series of important processes in life activity through the regulation of gene expression patterns,including cell proliferation, apoptosis,differentiation and individual development. Let-7 family is the second member of the miRNA family,discovered after Lin - 4 in 2000,and is thought to be related to the occurrence and development of tumor,cardiovascular diseases,viral infections and pulmonary diseases,especially. In this review,we focused on the recent research progress of miRNA Let-7 family and pulmonary diseases such as pulmonary cancer,bronchopulmonary dysplasia,pulmonary injury,pulmonary fibrosis and pulmonary inflammation.

关 键 词：微RNAS 基因调控 肺疾病 LET-7 

分 类 号：R342.2[医药卫生—基础医学] R563