N末端脑利钠肽前体与冠心病冠状动脉病变程度的关系研究  

Relationship between N-terminal pro-brain natriuretic peptide and severity of coronary artery lesions in coronary heart disease

作　　者：乔小民[1] 陶玲[1] 缪金龙 徐元胜[1] 杜涛[1] 

机构地区：[1]兰州市第二人民医院心内科,甘肃兰州730046

出　　处：《兰州大学学报（医学版）》2016年第3期48-51,共4页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的探讨冠心病患者N末端脑利钠肽前体(NT-proBNP)的水平与冠状动脉病变程度的关系。方法选取临床疑诊冠心病(左室射血分值≥50%)的患者105例,根据冠状动脉造影结果将患者分为冠心病组(79例)及对照组(26例)。冠心病组根据病变累及血管数目分为单支血管病变组、多支血管病变组。分别比较各组之间血浆NT-proBNP水平。结果冠心病组血浆NT-proBNP显著高于对照组(P<0.01),且数值随冠脉病变支数增加而增高。多支血管病变组血浆NT-proBNP水平高于单支血管病变组(P<0.05)。结论冠心病患者血浆NT-proBNP升高,NT-proBNP对于预测冠心病的严重程度有一定价值。Objective To investigate the relationship between N- terminal pro- brain natriuretic peptide（NT- proBNP） and the severity of coronary artery lesions in patients with coronary heart disease（CHD）.Methods One hundred and five patients with suspected CHD（LVEF 50%） were divided into CHD group（79 cases） and control group（26 cases） according to their coronary angiography. The patients in CHD group were divided again into single artery lesion group and multi-arteries lesion group according to the number of the involved arteries. The levels of plasma NT- proBNP were measured and analyzed among the groups.Results The levels of plasma NT-proBNP in CHD group were significantly higher than those of control group（P〈0.01） and the level of NT-proBNP was enhanced with the increasing of numbers of involved coronary artery, the plasma NT-proBNP levels in multi-arteries lesion group were higher than those in single artery lesion group（P〈0.05）. Conclusion The level of plasma NT-proBNP in CHD was increased and it can be one of the indicators to predict the severity of coronary heart disease.

关 键 词：冠心病 N末端脑利钠肽前体 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]