骨肽注射液对骨关节骨性关节炎患者碱性磷酸酶活性及临床疗效的影响  

Effect of bone peptide injection on alkaline phosphatase activity and clinical efficacy in patients with joint osteoarthritis

作　　者：张韬[1] 雷雪飞[2] 程建明[3] 

机构地区：[1]湖北医药学院附属东风医院中医科,湖北省十堰市442000 [2]湖北医药学院附属东风医院门诊检验科,湖北省十堰市442000 [3]湖北医药学院附属太和医院针灸科,湖北省十堰市442000

出　　处：《中国医药》2016年第7期1047-1050,共4页China Medicine

基　　金：湖北省教育厅科学技术研究项目（B20122406）

摘　　要：目的探讨骨肽注射液对骨关节骨性关节炎患者碱性磷酸酶活性及临床疗效的影响。方法选取2012年6月至2014年6月于湖北医药学院附属东风医院就诊的骨关节骨性关节炎患者112例，按就诊单双号分为观察组（57例）和对照组（55例）。对照组患者给予硫酸氨基葡萄糖口服，2粒／次，3次／d，连续给药6周为1个疗程。观察组患者给予骨肽注射液20支加入到0．9％氯化钠注射液中静脉滴注，1次／d，连续给药15d为1个疗程。治疗前和治疗15、30、45d时，检测并比较2组碱性磷酸酶活性，治疗45d后比较2组疗效及不良反应发生情况。结果治疗前观察组和对照组碱性磷酸酶活性差异无统计学意义[（0．54±0．05）nkat/L比（0．55±0．03）nkat/L]（P〉0．05），治疗15、30、45d时，观察组碱性磷酸酶活性均明显优于对照组[（0．83±0．06）nkat/L比（0．62±0．05）nkat/L、（0．96±0．04）nkaCL比（0．73±0．08）nkaCL、（1．36±0．07）nkat/L比（0．86±0．09）nkat/L]，差异均有统计学意义（均P〈0．05）。治疗后，观察组总有效率明显高于对照组[89．5％（51／57）比72．7％（40／55）]，不良反应发生率明显低于对照组[14．0％（8／57）比29．1％（16／55）]，差异均有统计学意义（均P〈0．05）。结论骨肽注射液能够明显提高骨关节骨性关节炎患者碱性磷酸酶的活性，临床疗效较好，安全性较高。Objective To investigate the effect of bone peptide injection on the activity of alkaline phos- phatase and the clinical efficacy in patients with joint osteoaxthritis. Methods Totally 112 patients with joint osteo- arthritis from June 2012 to June 2014 in Dongfeng Hospital Affiliated to Hubei Medical College were enrolled and randomly divided into observation group（57 cases）and control group（55 cases）. The control group was treated with glucosamine sulfate（ orally, 2 pills/time, 3 times/d, 6 weeks as 1 course）, the observation group was given 20 doses of bone pepfide injection mixed with 0. 9% sodium chloride by intravenous drip（ 1 time/d, 15 d as 1 course）. Activ- ities of alkaline phosphatase were analyzed before and 15, 30, 45 d after treatment, clinical efficacy and adverse re- actions were compared 45 d after treatment. Results Before treatment, alkaline phosphatase activities had no signif- icant difference between groups [ （0. 54 ± 0. 05 ）nkat/L vs （0. 55 ±0. 03 ）nkat/L] （P 〉 0. 05 ） ; 15, 30 and 45 d after treatment, alkaline phosphatase activities in observation group were all significantly higher than those in control group [ （0. 83 ± 0. 06 ） nkat/L vs （ 0. 62 ± 0. 05 ） nkat/L, （ 0. 96 ± 0. 04 ） nkat/L vs （ 0. 73 ± 0. 08 ） nkat/L, （ 1.36 ± 0. 07）nkat/L vs（0. 86 ±0. 09）nkat/L] （P 〈0. 05）. After treatment, the total effective rate was significantly higher and the rate of adverse reactions was significantly lower in observation group than those in control group [ 89. 5% （51/57） vs 72. 7% （40/55） ; 14. 0% （8/57） vs 29. 1% （ 16/55 ） ] （ P 〈 0. 05 ）. Conclusion Bone pepfide injection can effectively and safely improve the activity of alkaline phosphatase in patients with joint osteoarthritis.

关 键 词：骨关节骨性关节炎 骨肽注射液 碱性磷酸酶 活性 

分 类 号：R684.3[医药卫生—骨科学]