鼻渊汤辨证加减辅助免疫疗法治疗常年性变应性鼻炎的临床效果观察  

Clinical observation of Biyuan soup differentiation modified adjuvant immunotherapy on perennial allergic rhinitis

作　　者：王守玺[1] 任杰[1] 陈广杰[1] 刘荷珍[1] 黄继红[2] 

机构地区：[1]山东省菏泽市立医院耳鼻咽喉科,274031 [2]海南医学院附属医院耳鼻咽喉科,海口570102

出　　处：《中国医药》2016年第7期1072-1075,共4页China Medicine

基　　金：海南省卫生厅医学科研立项课题（琼卫2012PT-29）

摘　　要：目的探讨鼻渊汤辨证加减辅助免疫疗法治疗常年性变应性鼻炎的临床效果。方法选取2011年8月至2015年2月在山东省菏泽市立医院诊治的常年性变应性鼻炎患者120例，根据随机数字表法分为观察组与对照组，各60例。对照组给予常规西药免疫治疗，观察组在对照组基础上给予鼻渊汤辨证加减治疗，2组均治疗1个月。比较2组患者临床疗效，治疗前后鼻涕和鼻塞临床症状评分、免疫球蛋白（Ig）G4水平和治疗后过敏反应发生情况。结果治疗后，观察组治疗有效率明显高于对照组[96．7％（58／60）比83．3％（50／60）]，差异有统计学意义（P〈0．05）。治疗后，2组患者鼻涕和鼻塞临床症状评分均明显低于治疗前[观察组：（0．8±0．4）分比（4．5±0．4）分、（0．9±0．5）分比（4．6±0．6）分；对照组：（2．0±0．8）分比（4．5±0．5）分、（2．0±0．8）分比（4．6±0．4）分]，且观察组明显低于对照组，差异均有统计学意义（均P〈0．05）。治疗后，2组患者IgG4水平均明显高于治疗前[观察组：（33±12）mg/L比（10±7）mg／L；对照组：（24±9）mg/L比（10±7）mg／L]，且观察组明显高于对照组，差异均有统计学意义（均P〈0．05）。观察组治疗期间过敏反应发生率明显低于对照组[3．3％（2／60）比13．3％（8／60）]，差异有统计学意义（P〈0．05）。结论鼻渊汤辨证加减辅助免疫疗法治疗常年性变应性鼻炎能增强机体免疫功能，促进临床症状恢复，安全性较好。Objective To investigate the clinical effect of Biyuan soup differentiation modified adjuvant immunotherapy on perennial allergic rhinitis. Methods Totally 120 patients with perennial allergic rhinitis from August 2011 to February 2015 were randomly equally divided into observation group and control group. The control group was treated with routine medicine for immunization treatment and the observation group was added Biyuan soup differentiation modified adjuvant therapy; both groups were treated for 1 month. Clinical symptoln scores of nasal obstruction, immunoglobulin （Ig） G4 levels before and after therapy and the incidence of allergic reaction after therapy were analyzed between 2 groups. Results After therapy, the efficiency of observation group was sig- nificantly higher than that of control group [ 96.7% （58/60） vs 83.3% （50/60） 1 （ P 〈 0.05 ）. The clinical symptom scores of nasal obstruction after therapy was lower than those before therapy in both groups [ observation group： （0.8±0.4） scores vs （4.5±0.4） scores,（0.9±0.5） scores vs （4.6±0.6） scores; control group： （ 2.0 ± 0.8 ） scores vs （4.5 ± 0.5 ） scores, （ 2.0 ± 0.8 ） scores vs （4.6±0.4） scores I , and the scores in obser- vation group were lower than those in control group, the differences were all statistically significant （ P 〈 0.05 ）. The IgG4 levels after therapy were higher than those before therapy in both groups [ observation group： （33 ± 12） mg/L vs （ 10 ± 7 ） mg/L; control group： （24 ± 9） mg/L vs （ 10 ± 7） mg/L 1 , and observation group was higher than control group, the differences all had statistical significance （ P 〈 0.05 ）. The incidence of allergic reaction in observation group was lower than that in control group [ 3.3% （2/60） vs 13.3% （8/60） ] , and the difference was statistically significant （ P 〈 0.05 ）. Conclusion Biyuan soup differentiation modified adjuvant immunotherapy on perennial allergic rhinitis can enhance imm

关 键 词：常年性变应性鼻炎 鼻渊汤 辨证治疗 免疫疗法 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]