不同血液病患者发生自发性出血事件时的血小板特征  

Charactoristics of platelet in patients with different kinds of hematonosis during spontaneous bleeding

作　　者：胡文静[1] 周荣富[2] 贾璐[1] 张瑞生[3] 周镇先[4] 张红梅[5] 

机构地区：[1]南京红十字血液中心供血科,江苏省210003 [2]南京鼓楼医院血液科 [3]南京市第一医院输血科 [4]南京市第二医院输血科 [5]南京医科大学附属江宁医院输血科

出　　处：《江苏医药》2016年第11期1258-1260,共3页Jiangsu Medical Journal

基　　金：南京市医学科技发展项目(YKK14170);南京市科技发展指导性计划项目(2015ZD009)

摘　　要：目的分析血液病患者发生自发性出血事件时的血小板特征。方法收集南京市4所医院出现自发性出血症状的6种血液病患者322例的资料,包括再生障碍性贫血（AA,41例）、原发免疫性血小板减少症（ITP,102例）、急性髓细胞白血病（AML,90例）及其中的急性早幼粒细胞白血病（APL,43例）、骨髓增生异常综合征（MDS,24例）、急性淋巴细胞白血病（ALL,22例）。分析发生出血事件时的血小板计数、血小板平均体积与血小板分布宽度。结果发生自发性出血事件时,AML组（APL除外）、ALL组和APL组的血小板计数分别为（16.09±10.92）×10^9/L、（22.59±17.66）×10^9/L和（24.16±16.29）×10^9/L,均高于AA组的（7.42±4.68）×10^9/L和ITP组的（8.06±6.77）×10^9/L（P〈0.01）。ALL组和APL组出血时的血小板计数高于MDS组的（12.25±9.52）×10^9/L（P〈0.01）。六组患者发生自发性出血事件时的血小板平均体积和分布宽度无明显差异（P〉0.05）。结论 ALL与APL患者易出血,不能耐受较低的血小板计数。Objective To analyze the cheractoristics of platelet in patients with different kinds of hematonosis during spontaneous bleeding.Methods The data of 322 hematonosis patients with spontaneous bleeding symptoms were collected,of whom 41 cases were with aplastic anemia（AA）,102 cases with primary immune thrombocytopenia（ITP）,90 cases with acute myeloid leukemia（AML）,90 cases with acute promyelocytic leukemia（APL）,24 cases with myelodysplastic syndrome（MDS）and22cases with acute lymphatic leukemia（ALL）.The platelet count,average platelet volume and platelet distribution width were analyzed.Results when spontaneous bleeding events took place,the platelet count in groups of AML,ALL and APL were（16.09±10.92）×10^9/L,（22.59±17.66）×10^9/L and（24.16±16.29）×10^9/L,respectively,which was higher than（7.42±4.68）×10^9/L in group ITP and（8.06±6.77）×10^9/L in group ITP（P〈0.01）.The platelet count in groups of ALL and APL was higher than（12.25±9.52）×10^9/L in group MDS（P〈0.01）.There were no significant differences in average platelet volume and platelet distribution width among 6groups during bleeding time（P〈0.05）.Conclusion Patients with ALL and APL are easy to have spontaneous bleeding events and can not tolerate a relatively lower platelet count.

关 键 词：血液病 血小板 出血 

分 类 号：R457[医药卫生—治疗学]