妊娠期糖尿病产妇胎盘与血清脂联素水平的相关性  

The Relationship Between the Placenta and Serum Adiponectin Level in Patients with Gestational Diabetes Mellitus

作　　者：李华珍[1] 袁俏奇 罗利[1] 黄薇[1] 许金华[2] 

机构地区：[1]广州医科大学附属第四医院妇产科,广东广州511447 [2]南华大学护理学院

出　　处：《中南医学科学杂志》2016年第3期255-257,共3页Medical Science Journal of Central South China

摘　　要：目的探讨妊娠期糖尿病(GDM)产妇胎盘脂联素(APN)表达水平与血清脂联素、胰岛素抵抗的关系。方法选择2014年10月至2015年9月在本院分娩的30例GDM产妇作为研究组,随机抽取同时段分娩的正常产妇30例作为对照组。免疫组化法检测胎盘滋养层细胞APN表达水平,分析胎盘APN水平与胰岛素抵抗、血清APN水平、产前体重指数(BMI)、新生儿体重和身长的相关性。结果对照组胎盘滋养层细胞中可见细胞质、胞核或胞膜被染成棕黄色的阳性反应物,研究组阳性反应物的表达弱于对照组。定量分析显示,对照组APN的表达量为62.54±3.36,研究组APN的表达量为37.12±2.79,两组比较,差异有显著性(t=8.496,P=0.000)。胎盘滋养层APN水平与产前BMI、产前HOMA-IR、新生儿出生体重呈负相关(P<0.01),胎盘滋养层APN水平与产前血APN水平呈正相关(P<0.01),而与新生儿出生身长无相关性(P>0.05)。结论胎盘APN表达水平降低和孕妇血清APN水平、胰岛素抵抗与胎儿生长发育均有显著相关,对胎盘APN表达及作用机制的进一步研究可为GDM的防治提供新的思路。Objective To study the relationship of placenta adiponectin level with insulin resistance and serum adiponectin level in patients with gestational diabetes mellitus. Methods 30 patients in our hospital from October 2014 to September 2015 were selected as study group,and pregnant woman in childbirth at the same time were selected as control group.Immunohistochemistry was used to detect the expression level of APN in trophoblast cells.The relationship of placenta adiponectin level with insulin resistance, serum adiponectin level, prenatal body mass index, weight and length of newborn was analyzed. Results Positive reaction in placental trophoblast cells could be observed in the control group, and the ex- pression of the positive reaction in the study group was weaker than that in the control group.The expression amount of APN in control group and study group were （ 62.54±3.36 ） and （ 37.12±2.79） respectively （ t = 8.496, P = 0. 000）. The trophoblast APN level was negatively correlated with BMI in placenta, prenatal HOMA-IR and neonatal birth weight. The tropboblast APN level was positively correlated with prenatal blood APN level （P〈0.01）.The trophoblast APN level was not eorrelated with neonatal birth length （P〉0.05）. Conclusion The trophoblast APN level was correlated with prenatal blood APN leve,insulin resistance and fetal growth and development,further studies on expression and mechanism of APN in placenta can provide a new way of thinking for the prevention and treatment of GDM.

关 键 词：妊娠期糖尿病 脂联素 胎盘 

分 类 号：R71[医药卫生—妇产科学]