华东两市新生儿房间隔缺损和室间隔缺损检出情况及影响因素分析  

Detection Rates and Influencing Factors of Atrial Septal Defect and Ventricular Septal Defect Among Live Births in Two Cities of East China

作　　者：赵天明[1] 王增武[1] 张林峰[1] 王馨[1] 陈祚[1] 张甦 唐新华 祖秋菊[4] 胡立群 李守军[6] 逄坤静[7] 朱曼璐[1] 高润霖[8] 

机构地区：[1]北京协和医学院中国医学科学院国家心血管病中心阜外医院社区防治部,北京市100037 [2]湖州市妇幼保健院 [3]浙江省心脑血管病防治研究中心 [4]淮北市人民医院 [5]安徽医科大学附属省立医院安徽省心血管病研究所 [6]北京协和医学院中国医学科学院国家心血管病中心阜外医院小儿心脏外科,北京市100037 [7]北京协和医学院中国医学科学院国家心血管病中心阜外医院超声科,北京市100037 [8]北京协和医学院中国医学科学院国家心血管病中心阜外医院心内科,北京市100037

出　　处：《中国循环杂志》2016年第6期564-568,共5页Chinese Circulation Journal

基　　金："十二五"国家科技支撑计划项目"中国重要心血管病患病率调查及关键技术研究"(2011BAI11B01)

摘　　要：目的：了解华东两市新生儿房间隔缺损（ASD）和室间隔缺损（VSD）患儿的检出情况及其影响因素,为新生儿ASD和VSD的预防、诊治和监测提供科学依据。方法：以2013-09至2014-11期间两市各调查点连续出生的孕满28周的2 100例活产新生儿及其父母作为调查对象,在新生儿出生后0~7天内进行问卷调查和彩色多普勒超声心动图检查,收集ASD和VSD患儿及其父母的相关临床资料。结果：共筛查4 152例新生儿,其中男婴2 189例（52.72%）,胎龄为（39.18±1.48）周,产妇年龄为（26.54±4.36）岁。新生儿ASD和VSD检出率分别为60.5‰和12.8‰,且不同性别新生儿ASD和VSD检出率差异均无统计学意义（P〉0.05）。多因素Logistic回归分析发现产妇孕前体重指数和家居装修是新生儿ASD的影响因素,而产妇孕早期服药是新生儿VSD的影响因素。结论：华东两市新生儿ASD和VSD检出率较高,应采取针对性的综合干预措施,加强新生儿ASD和VSD的早期筛查,降低新生儿ASD和VSD的发生和改善预后。Objective： To investigate the detection rates and influencing factors of atrial septal defect （ASD） and ventricular septal defect （VSD） among neonates in two cities of East China and to provide scientific basis for the prevention, diagnosis, treatment and monitor of ASD and VSD. Methods： 2100 newborns with gestational age of at least 28 weeks were recruited consecutively from each city between 2013-09 and 2014-11. Data related to ASD and VSD were collected by questionnaires and echocardiographic screening was conducted within 7 days after birth. Results： A total of 4152 neonateswere examined with gestational age of （39.03 ± 1.29） weeks, among whom 2189 were male infants （52.72%）, and age of mother was （26.32 ± 4.10） years old. Detection rates of ASD and VSD were 60.5‰ and12.8‰ respectively, showing no significant difference between genders （P〉0.05）. Multivariate logistic regression analysis showed that maternal pre-pregnancy BMI and home decoration were the influencing factors of ASD and maternal drug use in early pregnancy was the influencing factor of VSD among newborns. Conclusions： Detection rates of ASD and VSD among neonates were relatively high in two cities of East China. Early screening is importtant to reduce the incidence of ASD and VSD and improve the prognosis.

关 键 词：房间隔缺损 室间隔缺损 新生儿 检出率 影响因素 

分 类 号：R541.4[医药卫生—心血管疾病]