赶黄草复方治疗酒精性脂肪肝临床观察  

Clinical Observation of Ganhuangcao Compound Treating Patients with Alcoholic Fatty Liver Disease

作　　者：王进博[1,2] 李正[1] 赵远红[1] 

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]天津中医药大学研究生院,天津300193

出　　处：《中国实验方剂学杂志》2016年第13期156-160,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：天津市西青区科技创新专项(XQCXZX2012-006);天津市西青区科技型中小企业发展专项(XQKC2013-022)

摘　　要：目的:观察赶黄草复方治疗酒精性脂肪肝(AFLD)的临床疗效,并探讨其作用机制。方法:将90例酒精性脂肪肝患者随机分为治疗组和对照组,各45例。对照组给予多烯磷脂酰胆碱静脉滴注治疗,治疗组除给予多烯磷脂酰胆碱滴注外,口服赶黄草复方。两组疗程均为4周,观察治疗前后两组临床疗效、肝功能、血脂、肝脏影像变化及药物不良反应。结果:治疗组总有效率为80%,对照组为60.22%,治疗组优于对照组(P<0.05)。治疗组在改善患者临床症状(乏力、黄疸、纳差、便溏),肝功能[丙氨酸氨基转移酶(ALT),谷酰转肽酶(GGT),γ-谷氨酰胺基转移酶(γ-GT)],血脂方面[甘油三酯(TG),低密度脂蛋白(LDL-C)]均优于对照组(P<0.05)。结论:赶黄草复方治疗酒精性脂肪肝疗效确切,值得深入研究促进临床应用。Objective： To observe the clinical effect of Ganhuangcao compound in the treatment of alcoholic fatty liver disease（ AFLD）. Method： The 90 patients with alcoholic fatty liver were randomly divided into treatment group and control group,with 45 cases in each group. Both of the two groups were injected with polyene phosphatidyl choline,and the treatment group was additionally given Ganhuangcao compound. The two groups were all treated for 4 weeks,and then their clinical efficacy,liver function,blood lipid,liver imaging changes and adverse drug reactions were observed. Result： The total effective rate was 80% in treatment group,and 60. 22% in control group,indicating a statistically significant difference between the two groups（ P 〈0. 05）.And the treatment group was superior to the control group in clinical symptoms,liver function and blood lipid（ P 〈0. 05）,with statistically significant differences in clinical symptoms,such as fatigue,jaundice,nacha,loose stools,liver function, such as alanine aminotransferase（ ALT）, gamma-glutamyltranspeptidase（ GGT）, γ-glutamine based transfer enzyme（ γ-GT）,and blood lipids,such as low density lipoprotein cholesterol（ LDL-C）,triglyceride（ TG）（ P 〈0. 05）. Conclusion： Ganhuangcao compound is effective in treatment of alcoholic fatty liver,and worthy of clinical application.

关 键 词：酒精性脂肪肝 多烯磷脂酰胆碱 赶黄草复方 临床观察 肝功能 血脂 

分 类 号：R287[医药卫生—中药学]