2012-2014年厦门市百白破疫苗接种后异常反应监测分析  

Analysis on the surveillance for adverse events following immunization with DPT vaccine in Xiamen City from 2012 to 2014

作　　者：吴默秀 李锦阳 池益强[2] 马姗姗[2] 谢群[2] 

机构地区：[1]厦门市湖里区疾病预防控制中心,福建厦门361009 [2]厦门市疾病预防控制中心,福建厦门361012

出　　处：《现代预防医学》2016年第12期2244-2246,2258,共4页Modern Preventive Medicine

摘　　要：目的分析百白破疫苗接种后疑似预防接种异常反应(AEFI)报告情况。方法对2012-2014年厦门市AEFI监测系统报告的百白破疫苗相关AEFI个案数据进行分析。结果厦门市6个区中,思明区报告发生率最高。各个月份均有病例报告,其中4、5、6、7、8、9各月份报告数较多。1岁年龄组报告病例最多,其次为0岁组,随着年龄上升,报告例数逐渐减少。加强免疫剂次的AEFI报告发生率最高,白破疫苗的报告发生率高于无细胞百白破疫苗。吸附性无细胞百白破+HIB+IPV联合疫苗AEFI报告发生率为79.1/10万,高于无细胞百白破。结论百白破成分疫苗接种4个剂次中加强剂次AEFI报告发生率最高,也高于白破疫苗的AEFI报告发生率。五联苗替代无细胞百白破疫苗不能降低AEFI报告发生率。Objective This work was to investigate the occurrence of adverse effects following immunization with DPT vaccine. Methods All data regarding the AEFI associated with immunization of DPT-containing vaccine reported by the surveillance system in Xiamen City were collected and analyzed. Results Among the 6 Districts of Xiamen City, the highest incidence was reported in Siming District. There were case reports every month, but reports relatively concentrated in April - September. The incidence among the 1 year-old age group was the highest, followed by 0 year old age group. The incidence decreased with increasing age. Incidence was higher to the immunization with booster doses. Incidence following Diphtheria vaccine immunization was higher than that of DTaP vaccine. The incidence of DTaP ＋ HIB ＋ IPV-related AEFI was 79.1/100000, which was higher than that of DTaP vaccines. Conclusion The incidence of AEFI during booster immunization of DVF- containing vaccine was higher than that of diphtheria-tetanus vaccine. Pentavaccine, as an alternative of cell-free DPT- containing vaccine, cannot reduce the incidence of AEFI.

关 键 词：疑似预防接种异常反应 无细胞百白破疫苗 白破疫苗 五联苗 剂次 

分 类 号：R186[医药卫生—流行病学]