玫瑰痤疮发病机制和治疗的最新进展  

The latest research progress of pathogenesis and treatment of acne rosacea

作　　者：杜丹[1] 杨笛[1] 郝丹[1] 蒋献[1] 

机构地区：[1]四川大学华西医院皮肤性病科,四川成都610041

出　　处：《中国美容医学》2016年第6期112-115,共4页Chinese Journal of Aesthetic Medicine

摘　　要：玫瑰痤疮的发病机制复杂,主要与血管舒缩功能障碍、神经血管调节功能异常以及皮肤天然免疫防御功能与屏障功能损害等相关。目前治疗上主要针对其炎症性病理生理过程以及皮肤屏障功能的修复。常用的治疗方法包括外用甲硝唑、壬二酸、伊维菌素、α-肾上腺素能受体激动剂、钙调磷酸酶抑制剂,口服四环素、维甲酸、β-肾上腺素能受体阻滞剂以及联合激光、手术等。本文将综述其发病机制及治疗方面的最新进展,为玫瑰痤疮的诊治提供一定参考。The pathogenic mechanism of rosacea is complicated, mainly related to vasomotor dysfunction, neurovascular dysregulation and skin innate immune defense and barrier functional impairment. Treatment at present mainly tagets the inlfammatory pathophysiological procedure and repairs the skin barrier function. Common therapeutic methods include topical agents such as metronidazole, azelaic acid, α-adrenoceptor agonist,retinoid acid, calcineurin inhibitors, and systemic therapies consist of tetracycline, ivermectin, β-adrenoceptor antagonist or combined with laser therapy and surgical operation, etc. In this paper, we will summary the latest research progress of pathogenesis and treatment of acne rosacea and provide certain reference for the diagnosis and treatment of rosacea.

关 键 词：玫瑰痤疮 发病机制 研究进展 神经血管调节异常 四环素 α-肾上腺素能受体激动剂 Β-肾上腺素能受体阻滞剂 伊维菌素 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]