T2-弛豫时间图对非压迫性腰椎间盘髓核突出症诊断价值的实验研究  

Value of T2-mapping in the diagnosis of non-compressive lumbar disc herniation ： an experimental research

作　　者：肖应权[1] 牛翔科 曾利川 杨汉丰[2] 

机构地区：[1]双流县中医医院放射科,四川省610000 [2]四川省南充市川北医学院附属医院CT介入室,637000

出　　处：《实用疼痛学杂志》2016年第2期91-95,共5页Pain Clinic Journal

基　　金：四川省杰出青年学术技术带头人后续资助计划（2012JQ0060）

摘　　要：目的观察T2-mapping成像对非压迫性腰椎间盘髓核突出症的诊断价值。方法全麻后对7头健康中国成年小型猪先进行T2-mapping序列扫描，而后CT导向下于L4-5、L3-6及L6～S1水平一侧椎间孔区各注入髓核匀浆2ml进行神经根炎症制模。造模后第14日，再次采用相同T2-mapping序列参数进行扫描。扫描所得T2-mapping原始图像传至工作站利用相应后处理软件重建T2值图像，并测定双侧L5、L5及S1神经根的平均T2值。采用配对t检验的方法分别比较造模侧神经根与对侧神经根及造模前自身之间的T2值有无差别。结果造模前实验猪脊神经根的平均MRI T2值左、右两侧评分别为：（52．5±1．5）vs（52．1±1．3），左、右两侧各值比较差异无统计学意义（P〉0．05）。造模后神经根平均T2值造模侧及对照侧分别为：（63．2±2．1）VS（51．7±2．0）（P〈0．05）。病理检查显示：造模侧神经根充血水肿、炎性细胞浸润，并部分膜性结构完整性被破坏。结论T2弛豫时间值测量可反映非压迫性椎间盘突出症漏出髓核液所致相邻区域神经根炎性改变。Objective To study the value of T2-mapping in the diagnosis of non-compressive lumbar disc herniation. Methods Seven healthy adult Chinese piglets were scanned with T2-mapping under general anesthesia before injecting 2 ml homogenated nucleus pulposus into one side of intervertebral foramen at the level of L4-5, L5-6 and L6-S1 under CT guidance to induce nerve root inflammation. After 14 days of making model, the pigs were scanned again with T2-mapping used the same method to obtain T2 values of bilateral L5,L6, S1 spinal nerve roots. Finally the T2 values were compared with their nontralateral normal nerve roots as well as the ipsilateral nerve root value obtained before induction of inflammation. Results The mean T2 values of bilateral nerve roots were （52.5 ± 1.5）vs（52.1 ± 1.3 ） respectively. There was no significant difference between the bilateral normal nerve roots（P〉 0.05）. After induction of inflammation, the mean T2 values of the contralateral nerve roots and the inflamed spinal nerve roots were （51.7 ± 2.0）vs（ 63.2 ± 2.1 ） respectively. There was statistical differenee （P 〈 0.05）. Pathological finding of the induced nerve root inflammation revealed that there were edema, infiltration of inflammatory cell and damage of the membrane structure. Conclusion The value of T2-mapping can reflect the characteristics of radiculitis caused by nucleus fluid leaked from adjacent disc.

关 键 词：磁共振成像 T2-mapping T2值 非压迫型腰椎间盘突出症 

分 类 号：R681.53[医药卫生—骨科学]