Toll样受体家族基因多态性与移植后相关疾病研究进展  

Progress on the association between polymorphisms of toll-like receptors and correlated disease after transplantation

作　　者：魏巴金[1,2] 周琳[1] 

机构地区：[1]浙江大学医学院附属第一医院器官移植重点实验室,杭州310003 [2]浙江大学医学院附属第一医院乳腺疾病诊治中心,杭州310003

出　　处：《中华移植杂志（电子版）》2016年第2期92-96,共5页Chinese Journal of Transplantation(Electronic Edition)

摘　　要：Toll样受体(TLRs)家族是人体固有免疫系统的重要组成部分,目前共有13种蛋白家族成员。TLRs通过识别病原相关分子模式,在固有免疫应答中发挥着重要的作用,被认为是连接人体固有免疫与获得性免疫的桥梁。近年来,关于TLRs家族和移植后相关疾病的研究(如排斥反应、移植物失功及感染等)取得了较大的进展。许多研究发现,TLRs家族基因多态性不仅可以影响TLRs家族基因的表达,与器官移植术后相关疾病也密切相关。本综述系统阐述了近年来TLRs家族基因多态性与移植后相关疾病的研究进展,希望为将来临床上开展同类研究提供一定的参考。Toll-like receptors（ TLRs） were a family receptor belonged to the pattern recognition receptors,which played a key role in innate immunity. There were 13 family members at present. TLRs activated the innate immune by recognizing pathogen-associated molecular patterns and they were considered as the bridge which could connect natural immunity and adaptive immunity. Great achievements had been obtained on the relationship between TLRs and correlated diseases after transplantation（ rejection,graft dysfunction,infection and so on） in recent years. Polymorphisms in TLRs were also found to not only influence expression of itsself but also correlated diseases after transplantation. This review tried to review progress on the association between polymorphisms of TLRs family and correlated disease after transplantation,hoping to provide reference for carrying forward similar research in the furture.

关 键 词：基因多态性 TOLL样受体 移植 

分 类 号：R392[医药卫生—免疫学]