黄芩苷磷脂复合物大鼠在体胃肠道吸收研究  

The Absorption of Baicalin Phospholipid Complex in Rat Stomach and Intestine

作　　者：李楠[1] 冯玲玲[1] 蒋学华[2] 杨明[1,3] 

机构地区：[1]成都中医药大学药学院,成都611137 [2]四川大学华西药学院,成都610041 [3]江西中医学院中药现代制剂教育部重点实验室,南昌330004

出　　处：《中国药学杂志》2016年第12期994-998,共5页Chinese Pharmaceutical Journal

摘　　要：目的研究黄芩苷磷脂复合物在大鼠胃、肠的吸收动力学特征。方法采用大鼠在体胃、肠吸收模型,以高效液相色谱法测定,比较黄芩苷、黄芩苷磷脂复合物以及黄芩苷和卵磷脂的物理混合物胃及全肠段吸收代谢特性;黄芩苷磷脂复合物分肠段吸收代谢特性。结果黄芩苷、黄芩苷磷脂复合物以及黄芩苷和卵磷脂的物理混合物在胃的每小时吸收百分率差异不大。黄芩苷磷脂复合物在小肠全肠段的吸收程度明显优于黄芩苷以及黄芩苷和卵磷脂的物理混合物,其累积吸收量为(2 940.87±1.45)μg,黄芩苷和卵磷脂的物理混合物为(1 373.23±3.21)μg,而黄芩苷最低为(992.66±3.65)μg;黄芩苷磷脂复合物在全肠段有广泛的吸收窗,十二指肠最优,十二指肠、空肠、回肠及结肠的吸收百分率为51.81%、32.29%、29.56%、11.80%。结论当黄芩苷制备成磷脂复合物后,可促进黄芩苷在大鼠胃肠道的吸收。OBJECTIVE To study the absorption kinetics of baicalin phospholipid complex in rats stomach and intestine.METHODS Using rats in vivo stomach and intestinal absorption mode,the drug concentration by in situ pefusion in rats were determined by HPLC to comparise the stomach、whole intestine absorption and metabolism characteristics among baicalin,baicalin phospholipid complex and physical mixture,and the sub-bowel absorption and metabolism characteristics of baicalin phospholipid complex.RESULTS The percentage of per hour absorpion in the stomach of baicalin,baicalin phospholipid complex and physical mixture shows little difference among them。The whole intestine absorption of baicalin phospholipid complex was better than the baicalin and physical mixture,which is（2 940.87 ± 1.45） μg,（1 373.23 ± 3.21） μg,（992.66 ± 3.65） μg,respectively.Baicalin phospholipid complex has extensive absorption window in the whole intestine and duodenum is the best。The absorption percentage of duodenum,jejunum,ileum and colon is 51.81% 、32.29% 、29.56% 、11.80%,respectively.CONCLUSION Baicalin phospholipid complex can significantly enchance absorption of baicalin in rat gastrointestinal tract.

关 键 词：黄芩苷 磷脂复合物 在体胃肠吸收 

分 类 号：R969[医药卫生—药理学]