锦州六价铬污染区居民外周血红细胞参数及尿铬的分析  

Parameters analysis of peripheral red blood cell and urine of residents in Jinzhou hexavalent choromium polluted area

作　　者：陈洁瑛[1] 魏岚萍[2] 柳晓琳 程晓萍 许群[1] 

机构地区：[1]中国医学科学院基础医学研究所北京协和医学院基础学院流行病与卫生统计学系,北京100005 [2]锦州市中心医院,辽宁锦州121001 [3]锦州医科大学公共卫生学院,辽宁锦州121001

出　　处：《基础医学与临床》2016年第7期990-994,共5页Basic and Clinical Medicine

基　　金：环保公益项目(201309045)

摘　　要：目的探讨长期六价铬接触对居民的外周血红细胞(RBC)参数及尿铬的影响。方法以锦州某有50年六价铬污染历史的铁合金厂为中心,采取整群随机抽样方法,选取附近村庄的135名居民进行健康调查,并采集其空腹外周静脉血和晨尿用于检测、分析。结果对不同外周血红细胞参数与居民尿铬水平进行稳健回归分析,调整性别、年龄、BMI,吸烟和饮酒等因素后,随着尿铬浓度增加,RBC数量下降(β=-0.09,P<0.01),而MCH(β=1.71,P<0.01)、MCV(β=0.29,P<0.05)上升。进一步分层分析发现,MCV在不同性别间及≤60岁的人群中与尿铬水平存在关联(P<0.05)。RBC在女性中与尿铬水平有关联(P<0.05),而MCHC在男性中有关联(P<0.05)。结论长期暴露于六价铬污染对当地居民的外周血红细胞参数产生了一定的影响。RBC随尿铬浓度升高而减少,而MCH与MCV水平呈现随尿铬升高而增大的现象。Objective To evaluate the residents＇ status of peripheral red blood cell in hexavalent chromium polluted are- as. Methods 135 residents in Jinzhou were randomly selected nearby an alloy plant with 50 years of hexavalent chromi- um by cluster sampling method. We conducted a questionnaire-based survey and collected blood and urine sample. ResultsBy using robust regression model adjusted for age, sex, smoking, drinking and BMI, we find association of chro- mium in urinary with RBC （β = -0. 09 ,P 〈0. 01 ） ,MCH（ β= 1.71 ,P 〈0. 01 ） and MCV（ β =0. 29 ,P 〈0. 05） respective- ly. Further analysis showed that MCV＇s relation with urinary chromium limited to individuals younger than 60. The asso- ciation with RBC was only seen for women and the association with MCHC was only seen for men. Conclusions Expo- sure to hexavalent chromium in the environment have chronic and long-term impact to peripheral red blood cell.

关 键 词：六价铬 污染 环境暴露 红细胞 

分 类 号：R114[医药卫生—卫生毒理学]