脂联素与银屑病的研究进展  

Adiponectin and its correlation with psoriasis

作　　者：鹿洪艳 宋顺鹏[1] 吕成志[1] 

机构地区：[1]大连市皮肤病医院银屑病专科,116021

出　　处：《国际皮肤性病学杂志》2016年第4期222-225,共4页International Journal of Dermatology and Venereology

摘　　要：脂肪组织不仅是一种存储过剩能量的组织，也是一个活跃的内分泌器官，可分泌多种生物活性物质，如瘦素和脂联素等，这些物质称为脂肪因子，是体内营养状态与神经内分泌-免疫系统之间相互作用的重要介质。脂肪细胞和巨噬细胞均参与释放促炎症因子，如肿瘤坏死因子、白细胞介素6、白细胞介素8、单核细胞趋化蛋白1及脂肪因子（脂联素、瘦素、抵抗素等）。其中，脂联素不仅与肥胖及胰岛素抵抗有密切关系，还具有抗炎及血管保护作用。肿瘤坏死因子α和白细胞介素6等其他细胞因子可在体外抑制脂联素的产生，而脂联素可以抑制角质形成细胞和T淋巴细胞产生肿瘤坏死因子α、白细胞介素6、17、22和干扰素γ。脂联素水平与银屑病的严重程度及肿瘤坏死因子α和白细胞介素6的水平呈负相关。Adipose tissue not only can store excess energy, but also serves as an active endocrine organ secreting a variety of bioactive substances, such as leptin and adiponectin. These substances are called adipokines, and are important mediators of the interaction between host nutritional status and the neuroendocrine-immune system. Adipocytes and macrophages both participate in the release of proinflammatory cytokines, such as tumor necrosis factor （TNF）, interleukin-6 （IL-6）, IL-8, monocyte chemotactic protein-1 （MCP-1） and adipokines （including adiponectin, leptin, resistin, and so on）. Adiponectin is not only closely associated with obesity and insulin resistance, but also has anti？-inflammatory and vascular protective effects. Some cytokines such as TNF-α and IL？-6 can inhibit the of adiponectin in vitro, while adiponectin can suppress the secretion of TNF-α, IL-6, IL-17, IL-22 and interferon γ by keratinocytes and T lymphocytes. The level of adiponectin is negatively correlated with the severity of psoriasis as well as levels of TNF-α and IL-6.

关 键 词：银屑病 脂联素 受体 脂联素 脂肪因子类 信号传导 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]