慢性自身免疫性荨麻疹研究进展  

Chronic autoimmune urticaria

作　　者：吕纯鹏 康尔恂[2] 

机构地区：[1]青岛大学,266071 [2]青岛大学医学院附属烟台毓璜顶医院皮肤科

出　　处：《国际皮肤性病学杂志》2016年第4期233-235,共3页International Journal of Dermatology and Venereology

基　　金：山东省科技发展计划（2011GSF11819）

摘　　要：慢性自身免疫性荨麻疹发病以自身免疫反应为基础。这类有自身抗体参与的慢性自身免疫性荨麻疹在预后和治疗上均有其特殊性，常规的抗组胺药物治疗很难奏效。研究发现，慢性自身免疫性荨麻疹的发病原因与抗IgE及其受体的自身抗体、自身免疫性甲状腺疾病以及幽门螺杆菌感染、遗传因素、精神因素等诸多因素有关。慢性自身免疫性荨麻疹患者体内B淋巴细胞刺激因子水平增高，刺激产生抗IgE的高亲和力受体抗体和抗IgE抗体，与肥大细胞结合后诱发自身免疫性荨麻疹。The occurrence of chronic autoimmune urticaria （CAU） is based on autoimmune responses. CAU with the involvement of autoantibodies shows distinctive prognosis and treatment, and routine antihistamine treatment hardly works. Studies have found that the etiology of CAU is associated with autoantibodies against IgEs and their receptors, autoimmune thyroid diseases, Helicobacter pylori infection, genetic factors, mental factors, etc. In addition, the level of B cell-stimulating factor is elevated in patients with CAU, and it can stimulate the production of antibodies against IgEs and their high-affinity receptors （anti-FcεRI）, which then bind to mast cells and finally result in the occurrence of urticaria.

关 键 词：荨麻疹 诊断 治疗应用 幽门螺杆菌 自身抗体 慢性自身免疫性荨麻疹 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]