代谢组学技术及其在药学研究领域的应用  

Metabonomics technology and its application in the field of pharmaceutical research

作　　者：陈晓[1] 李涵[2] 陈曦[2] 胡海[3] 张红菱[3] 

机构地区：[1]武汉轻工大学生物与制药工程学院,湖北武汉430023 [2]华中科技大学同济医学院公共卫生学院,湖北武汉430032 [3]武汉轻工大学医学技术与护理学院,湖北武汉430023

出　　处：《武汉轻工大学学报》2016年第2期12-15,共4页Journal of Wuhan Polytechnic University

摘　　要：代谢组学是近年来兴起的一门学科,其研究对象主要是能反映生物体所处环境的生物体液、生物标本、细胞提取物、细胞培养液和组织,并利用核磁共振和质谱等技术进行分析。在药学研究领域已成为研究的热点。对代谢组学的概况、分析技术及其近些年在药学研究领域中的应用进行了综述,并对代谢组学这一研究方法的优缺点进行小结。Metabonomics is a new science and technology developed in recent years. Major research objects of metabonomics are biological fluids which could reflect the environment of organisms,biological specimen,cell extracts,cell culture fluid and tissue,while NMR and MS are used as analysis methods. Metabonomics has been a research hotspot in the field of pharmacy. This paper reviews the analytical methods and the applications of metabolomics and summarize the advantages and disadvantages of metabolomics.

关 键 词：代谢组学 药学 毒理学 

分 类 号：R96[医药卫生—药理学]