特应性皮炎Th1/Th2/Th17平衡的研究  

Study on Th1/Th2/Th17 balance in atopic dermatitis

作　　者：蒋有让[1] 刁庆春[1] 史丙俊[1] 王樱霖[1] 徐可佳[1] 冯林[1] 

机构地区：[1]重庆市中医院/重庆市第一人民医院皮肤科,400011

出　　处：《重庆医学》2016年第18期2482-2483,共2页Chongqing medicine

基　　金：重庆市卫生局中医科研计划立项目录(2011-2-102;2012-2-182);重庆市自然科学基金资助项目(cstc 2012jjA 10141)

摘　　要：目的探讨特应性皮炎(AD)外周血清Th1/Th2/Th17平衡的变化规律及相关细胞因子的变化规律,以进一步探讨AD发病的免疫机制。方法采用流式荧光技术测定47例AD患者(AD组)和40例健康自愿者(对照组)外周血清中的γ-干扰素(IFN-γ)、白细胞介素(IL)-4、IL-17、IL-21、IL-23水平并进行统计分析,从而分析Th1/Th2/Th17/Treg平衡在AD中变化规律。结果在AD患者血清中,IL-4水平较对照组升高(P<0.05),IL-17、IL-23的水平显著高于对照组(P<0.05);IFN-γ/IL-4和IFN-γ/IL-17较对照组明显降低(P<0.01);IL-17与AD严重程度(SCORAD)评分呈正相关(P<0.05)。结论在AD病程中Th1/Th2、Th1/Th17降低,Th1/Th2/Th17平衡的漂移可能是AD发病的重要机制。Objective To research the change rule of peripheral serum Th1/Th2/Th17 balance and relevant cytokines in atopic dermatitis（AD） and to further study its immunologic mechanism .Methods The levels of peripheral serum IFN‐γ,IL‐4 ,IL‐17 ,IL‐21 and IL‐23 in the patients with AD were detected by the flow immunofluorescence technology and the detection results were performed the statistical analysis ,thus the change rule of Th1/Th2/Th17 balance in AD was analyzed .Results The IL‐4 level in peripheral serum of the patients with AD was increased compared with the healthy control group （P〈0 .05）;the IFN‐γ/IL‐4 and IFN‐γ/IL‐17 in the AD group were significantly decreased compared with the control group （P〈0 .01）;IL‐17 was positively corre‐lation with SCORAD scores of AD severity （P〈0 .05） .Conclusion Th1/Th2 and Th1/Th17 are decreased in the AD course .Th1/Th2/Th17 balance drift may be the important mechanism of AD pathogenesis .

关 键 词：特应性皮炎 细胞因子类 TH1细胞 TH2细胞 Th17细胞 流式荧光技术 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]