银杏叶胶囊联合雷公藤多苷治疗DN疗效和对患者CysC、Hcy及VEGF的影响  

Efficacy of Ginkgo-Leaf Capsule combined with tripterygium glycoside in treating diabetic nephropathy and its influence on CysC,Hcy and VEGF

作　　者：王妍君[1] 黄静蓉[1] 

机构地区：[1]青海大学附属医院肾内科,西宁810001

出　　处：《重庆医学》2016年第18期2513-2515,共3页Chongqing medicine

摘　　要：目的探讨银杏叶胶囊联合雷公藤多苷治疗糖尿病肾病(DN)疗效及对患者胱抑素C(CysC)、同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)水平的影响。方法选取2013年1月至2015年4月于该院接受治疗的DN患者80例,按照随机数字表法随机分为对照组和观察组(n=40)。在常规西医治疗基础上,对照组给予雷公藤多苷治疗,观察组在对照组基础上联合银杏叶胶囊治疗。疗程3个月,比较两组患者临床疗效、肾功能指标、CysC、Hcy、VEGF水平及不良反应发生情况。结果观察组和对照组治疗总有效率分别为92.50%和80.00%,组间比较差异无统计学意义(P>0.05)。与对照组相比,治疗后观察组肾功能指标血肌酐、尿素氮、24h尿蛋白量、CysC、Hcy、VEGF水平显著下降(P<0.05)。治疗期间,两组患者均未出现严重不良反应,观察组和对照组不良反应发生率分别为17.50%和12.50%,组间比较差异无统计学意义(P>0.05)。结论银杏叶胶囊联合雷公藤多苷治疗DN疗效可靠,能够明显改善肾功能,降低血清CysC、Hcy、VEGF水平。Objective To investigate the efficacy of Ginkgo‐Leaf Capsule combined with tripterygium glycoside in the treat‐ment of diabetic nephropathy（DN） and its influence on CysC ,Hcy and VEGF .Methods Eighty patients with DN treated in our hospital from January 2013 to April 2015 were selected as research subjects and equally divided into the control group and the ob‐servation group according to the random number table ,40 cases in each group .Besides the conventional Western medicine treat‐ment ,the control group was given tripterygium glycoside ,while the observation group was given Kinkgo‐Leaf Capsule combined with tripterygium glycoside .The treatment course was 3 months .Then ,the curative efficacy ,indices of renal function ,levels of Cy‐sC ,Hcy and vascular endothelial growth factor（VEGF） ,and occurrence situation of adverse reactions were compared between the two groups .Results The total therapeutic efficacy rate in the observation group and the control group was 92 .50% and 80 .00%respectively without statistically significant difference （P〉0 .05） .In the comparison with the control group after treatment ,the re‐nal function indices of serum creatinine ,urea nitrogen ,24 h urinary protein ,level of serum CysC ,Hcy and VEGF in the observation group were statistically decreased （P〈 0 .05） .During the treatment process ,no severe adverse reactions occurred in the two groups .The incidence rate of adverse reactions in the observation group and the control group was 17 .5% and 12 .5% respectively without statistical difference （P〉0 .05） .Conclusion Ginkgo‐Leaf Capsule combined with tripterygium glycoside is effective and reliable for treating DN ,which can significantly improve the renal function ,reduces the level of serum CysC ,Hcy and VEGF .

关 键 词：银杏叶胶囊 雷公藤多苷 糖尿病肾病 肾功能 胱抑素C 同型半胱氨酸 血管内皮生长因子 

分 类 号：R587.2[医药卫生—内分泌]