0～6月婴儿骨生化标志物与胰岛素样生长因子-I影响因素分析  

Analysis of Influence Factors of Biochemical Markers of Bone and IGF-I among 0～6 Months Infants

作　　者：孙瑞[1] 王鉴 

机构地区：[1]贵州医科大学 [2]贵州医科大学附院儿科,贵州贵阳550004

出　　处：《贵阳医学院学报》2016年第6期700-705,共6页Journal of Guiyang Medical College

基　　金：贵州省科技厅科学技术基金[黔科合J字(2009)2160号]

摘　　要：目的：探讨胎龄、出生季节、感染对0～6月婴儿骨生化标志物与胰岛素样生长因子-I（IGF—I）的影响。方法：109例新生儿根据胎龄分早期早产儿组（37例）、晚期早产儿组（41例）及足月儿组（31例），根据出生季节分春季组（25例）、夏季组（28例）、秋季组（29例）及冬季组（27例），早产儿根据是否感染分为感染组（42例）和非感染组（36例）；检测各组婴儿出生后1h、7d、3月及6月时的血清钙、磷、维生素D3（VitD3）、骨源性碱性磷酸酶（BAP）及IGF-I。结果：被检婴儿血清VitD3、钙、IGF—I水平随胎龄增加而升高（P〈0．05），VitD3、钙水平随日龄增加而升高（P〈0．05）；早产儿血清IGF—I水平随日龄增加而升高（P〈0．05），血清BAP、磷水平随着新生儿胎龄、日龄增加而降低（P〈0．05）；非感染组早产儿血清VitD3、钙、IGF—I水平较感染组高，BAP、磷水平较感染组低（P〈0．05）；血清VitD3、钙及IGF—I水平按秋季、夏季、春季及冬季依次降低（P〈0．05），BAP及磷水平依次升高（P〈0．05）。结论：胎龄、感染及出生季节对0～6月婴儿不同日龄的骨生化标志物及IGF—I有影响。Objective： To investigate the effect of gestational age, birth season and infection on biO- chemical markers of bone and Insulin-like Growth Factor-I （IGF-I） in 0 -6 month newborns. Meth- od： According to different gestational age, 109 newborns （born in hospital from Mar. 2014 to Jun. 2015） were divided into early-preterm group （ n = 37 ）, late-preterm group （ n = 41 ） and full-term group （ n =31 ）. According to birth season, 109 newborns were divided into spring group （ n = 25 ）, summer group （ n = 28 ）, autumn group （ n = 29） and winter group （ n = 27 ）. According to infected or not, premature infants were divided into infected and non-infected group. Then serum levels of calcium （ Ca）, phosphorus（ P）, vitamin D3（VitD3 ）, bone alkaline phosphatase（BAP） and IGF-I were detec- ted in each group on 1st hour, 7th day, 3rd month and 6th month after born, respectively. Results： The levels of VitD3, Ca, IGF-I was increased with gestational age in all group, and the difference was sta- tistically significant （P 〈 0.05 ）. The levels of VitD3, Ca increased with age in days in all groups, and the difference was statistically significant（P 〈0.05 ）. The level of IGF-I increased with age in days in early-preterm and late-preterm, and the difference was statistically significant （P 〈 0.05 ） ; The levelsof BAP and P decreased with gestational age and age in days in all groups, and the difference was sta- tistically significant （P 〈 0. 05 ）. The levels of VitD3, Ca and IGF-I in non-infected premature infants were significantly higher than their counterparts in infected premature infants while the levels of BAP and P in non-infected premature infants significantly lower than those of infected premature infants （P 〈 0.05 ）. The levels of VitD3, Ca and IGF-I decreased with the order of autumn, summer, spring and winter group, and the difference was statistically significant （P 〈 0.05 ） while the levels of BAP and P increased with the

关 键 词：婴儿  早产 维生素D3 碱性磷酸酶 胰岛素样生长因子-I 钙 磷 

分 类 号：R725[医药卫生—儿科]