未经抗病毒药物治疗的男性HIV/AIDS患者骨密度变化相关因素分析  

Factors influencing bone mineral density in ARV-naive HIV / AIDS male patients

作　　者：王晶晶[1] 张强[1] 陈宗锋[1] 赵汝刚 李鑫[1] 赵昌松[1] 刘琨[1] 

机构地区：[1]首都医科大学附属北京地坛医院骨科,北京100015

出　　处：《中国矫形外科杂志》2016年第13期1207-1210,共4页Orthopedic Journal of China

基　　金：国家科技重大专项项目(编号:2012ZX10004-904);首都临床特色应用研究项目(编号:Z131107002213063)

摘　　要：[目的]观察未经抗病毒药物治疗的男性人类免疫缺陷病毒感染/获得性免疫缺陷综合征（human immunodeficiency virus infection/acquired immune deficiency syndrome,HIV/AIDS）患者骨密度（bone mineral density,BMD）情况,初步探讨骨密度降低的影响因素。[方法]2014年1月～2015年1月就诊于本院的120例未经抗病毒治疗的男性HIV/AIDS患者,采用定量跟骨超声骨密度仪（quantitative ultrasound bone mineral density meter,QUS）测定患者骨密度,收集年龄、体重指数（BMI）、CD4＋T细胞水平、HIV感染时间、HIV病毒载量等指标,对数据进行统计学分析。[结果]未经抗病毒药物治疗的男性HIV/AIDS患者中,骨密度降低发生率为52/120（43.33%）,其中骨质疏松占11/120（9.17%）,骨量减少占41/120（34.17%）。骨密度正常组与骨密度降低组年龄、HIV病毒载量之间存在差异。经多因素Logistic回归分析结果显示年龄、HIV病毒载量为骨密度降低的危险因素。[结论]未经抗病毒药物治疗的男性HIV/AIDS患者年龄越大,HIV病毒载量越高,骨密度降低越明显。[Objective] To evaluate factors which influence bone mineral density（ bone mineral density,BMD） in ARV- naive HIV / AIDS（ human immunodeficiency virus infection / acquired immune deficiency syndrome,HIV / AIDS） male patients. [Methods] From January 2014 to January 2015,cross- sectional BMD was measured by QUS at the left heel in 120 ARV- naive HIV- infected patients in out patient clinic of Beijing Ditan Hospital,consecutively. The relationship among various influencing factors,such as BMD,age,BMI,HIV infection time,CD4 level,HIV RNA,was analyzed with Anova and Spearman＇s correlation test. [Results] Low BMD was found in 52 patients（ 52 /120,43. 33%）. Osteopenia and osteoporosis were diagnosed in 41 patients（ 41 /120,34. 17 %） and 11 patients（ 11 /120,9. 17%）. Significant differences were found in age and HIV viral load between normal bone mineral density group and low bone density group,indicating a significant correlation of low BMD to HIV RNA and age. [Conclusion] ARV- naive patients with higher HIV RNA and elder age have higher risk of low BMD.

关 键 词：人类免疫缺陷病毒感染 骨密度 超声骨密度 危险因素 

分 类 号：R512.91[医药卫生—内科学] R580[医药卫生—临床医学]