西洋参三七黄芪胶囊的制剂工艺研究  

Preparation of Xiyangshen Sanqi Huangqi Capsule

作　　者：王贤英[1] 谢香菊[1] 王钧[1] 李胜容[1] 

机构地区：[1]重庆市中药研究院,重庆400065

出　　处：《中国药业》2016年第12期19-22,共4页China Pharmaceuticals

基　　金：重庆市科技计划项目;项目编号:cstc2013yykfA0239

摘　　要：目的优化西洋参三七黄芪胶囊的制剂工艺。方法采用单因素试验,以休止角、堆密度、吸湿性、临界相对湿度为考察指标,筛选制粒最佳辅料、配比及最佳制剂工艺,并确定胶囊型号及装量。结果最佳制剂工艺条件为西洋参粉、三七粉、黄芪浸膏与淀粉按11∶11∶16∶5的比例混匀,过20目筛制粒;所制颗粒流动性适中,临界相对湿度为65%,堆密度为0.502 6 g/mL,选用0号胶囊,每粒装0.35 g。结论该制剂工艺合理、可行,可为大生产提供科学依据。Objective To optimize the preparation technology of Xiyangshen Sanqi Huangqi Capsule. Methods With the formulation, an- gle of repose, bulk density, percentage of moisture absorption, and critical relative humidity as index, the suitable exeipients and matching were selected,the type and filling capacity of capsule were chosen by single factor method. Results The optimal granulating technology was as following： the ratio of the Xiyangshen powder,Sanqi powder,Huangqi extract to starch was 11 ： 11 ： 16 ： 5,20 mesh;The parti- cles on the system of liquidity is moderate,critical relative humidity of 65% ,bulk density of 0. 502 6 g/mL,capsule 0,capsule weight of 0. 35 g. Conclusion The formulation technology is stable,reasonable,and can provide reliable basis for mass production.

关 键 词：西洋参三七黄芪胶囊 制剂工艺 临界相对湿度 

分 类 号：R286[医药卫生—中药学] R284.1[医药卫生—中医学]