不同药物麻醉预处理对颅脑手术患者脑功能的影响  

Influence of Anesthetic Pretreatment with Different Drugs on Brain Function in Patients with Brain Surgery

作　　者：利鸿胜[1] 彭丽云[1] 莫朴[1] 

机构地区：[1]广东省茂名市人民医院,广东茂名525000

出　　处：《中国药业》2016年第12期49-51,共3页China Pharmaceuticals

摘　　要：目的探讨不用药物麻醉预处理对颅脑手术患者脑功能的影响。方法选取医院行颅脑手术患者84例,按随机数字表法分为观察组与对照组,各42例。观察组患者采取丙泊酚联合利多卡因麻醉预处理方式,对照组患者单独采取丙泊酚麻醉预处理方式。比较两组患者经麻醉预处理术后的神经功能缺损(NFA)评分、运动功能测定(FMA)评分、汉密尔顿抑郁量表(HAMD)评分、Barthel指数、神经元特异性烯醇化酶(NSE)含量及超氧化物歧化酶(SOD)含量变化。结果治疗后,观察组颅脑手术患者的NFA评分为(14.09±3.25)分,FMA评分为(63.43±14.81)分,Barthel指数为(47.56±30.11)分,HAMD评分为(3.15±1.44)分,NSE含量为(22.04±7.38)μg/L,SOD含量为(1 268±423)μg/L,均明显优于对照组的(17.89±5.42)分,(52.33±12.49)分,(33.37±24.49)分,(5.99±3.66)分,(25.97±8.81)μg/L,(1 074±410)μg/L(P<0.05)。结论对颅脑手术患者采用丙泊酚联合利多卡因麻醉预处理后,患者NSE含量及SOD含量均明显改善,神经功能、运动功能及日常生活能力等评分明显提高,对患者脑功能影响较小,有助于颅脑手术患者术后恢复。Objective To analyze and investigate the influence of anesthetic pretreatment with different drugs on the brain function after brain surgery. Methods 84 patients with brain surgery in the hospital were divided into the observation group and the control group according to the random number table method, 42 patients in each group. The observation group received anesthetic pretreatment of propofol combined with lidoeaine,the control group received propofol pretreatment only. The NFA score,FMA score,HAMD score,Barthel index, NSE content and SOD content were compared in the two groups after the anesthetic pretreatment. Results In the observation group, the NFA score was （14. 09± 3.25） points, FMA score was（63.43 ± 14.81） points, Barthel index was （47.56 ±30.11） points, HAMD score was（3.15 ± 1.44） points, NSE content （22.04 ±7.38）μg/L, and the content of SOD was （1 268 ＋ 423） μg/L, which were significantly better than （17.89±5.42） points, F （52.33±12.49） points, （33.37±24.49） points, （5.99±3.66） points, （25.97±8.81） μg/L,and （1 074 ±410） μg/L in the control group（ P 〈 0.05）. Conclusion After anesthetic pretreatment of propo- fol combined with lidocaine for the brain surgery patient,the NSE content and SOD content have been significantly improved,the neuro- logical function, motion function and daily living and other scores are significantly improved with small impact on the brain funciton, which is conducive to the postoperative recovery of brain surgery.

关 键 词：丙泊酚 利多卡因 麻醉预处理 脑功能 颅脑手术 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]