丹参多酚酸盐对慢性阻塞性肺疾病急性加重患者炎性反应及氧化应激的影响  

Effect of Salvianolate Injection on Inflammatory Response and Oxidative Stress in Patients with Acute Exacerbated Chronic Obstructive Pulmonary Disease

作　　者：李双拾 耿秀娟 远丽娜 

机构地区：[1]辽宁省本溪市中心医院呼吸内科,辽宁本溪117000

出　　处：《中国药业》2016年第12期51-54,共4页China Pharmaceuticals

摘　　要：目的探讨丹参多酚酸盐注射液对慢性阻塞性肺疾病急性加重(AECOPD)患者炎性反应及氧化应激的影响。方法选取2013年2月至2015年10月在医院呼吸内科住院治疗的AECOPD患者130例,按随机数字表法分为对照组和治疗组,各65例。两组患者均给予抗感染、解痉平喘、化痰等常规治疗,治疗组患者在此基础上静脉滴注丹参多酚酸盐200 mg,1次/日。两组均治疗14 d。治疗前后分别进行慢性阻塞性肺疾病量表(CAT)评分及肺功能检查,同时采用酶联免疫吸附试验(ELISA)法检测血清8-异前列腺素(8-iso PG)、白细胞介素(IL)-18、IL-1β水平,并与65名健康体检者(正常对照组)的血清水平进行对照。结果治疗前,两组患者第1秒用力呼气容积(FEV1)占预计值百分比(FEV1%)、FEV1/用力肺活量(FVC)、CAT评分,以及血清8-iso PG,IL-18,IL-1β水平差异均无统计学意义(P>0.05),但两组患者FEV1%,FEV1/FVC和血清8-iso PG,IL-18,IL-1β水平均明显高于正常对照组(P<0.01);治疗后,两组患者FEV1%和FEV1/FVC均有明显提高,CAT评分及血清8-iso PG,IL-18,IL-1β水平均较治疗前明显降低(P<0.01或P<0.05),观察组CAT评分及血清8-iso PG,IL-18,IL-1β水平与对照组相比,均有明显差异(P<0.05)。结论丹参多酚酸盐注射液通过抑制炎性反应和减少氧化应激,可改善AECOPD患者肺功能指标及生活质量,且临床治疗安全、有效,无严重不良反应,值得临床推广。Objective To investigate the effects of Salvianolate Injection on inflammatory response and oxidative stress in patients with Acute exacerbated chronic obstructive pulmonary disease（AECOPD）. Methods 130 patients with AECOPD who were hospitalized in the department of respiration in the hospital from February 2013 to October 2015 were selected and divided into the control group and the treatment group,65 cases in each group. The two groups were given routine therapies,while on this basis 200 mg Salvianolate Injection was added to the treatment group by intravenous dripping,once daily for totally 14 d. The changes of 8-isoPG,IL-18,IL-1β,the pulmonary functions and CAT scores before and after treatment were evaluated in the two groups, and were compared with those of 65 healthy controls. Results Before treatment, the differences in the FEV1%, FEV1/FVC, CAT volume table score,and serum 8-isoPG, IL-18,IL-1β levels in the two groups were not statistically signifieant（P 〉 0.05）,hut FEV1% ,FEV1/FVC and serum 8-isoPG, IL- 18,1L-1β levels were significantly higher than the normal control group. Compared with before treatment,FEV1% and FEV1/FVC in the two groups increased significantly after treatment,CAT scores and serum 8-isoPG,IL-18,IL-1β levels decreased significantly（P 〈 0.01 or P 〈 0. 05）. After treatment,the serum levels of 8 -isoPG,IL- 18,IL- 1β and CAT scores in the treatment group were significantly different from the control group （P 〈 0.05）. Conclusion Salvianolate Injection can improve the lung function index in patients with AECOPD,reduce CAT scale scores,improve the quality of life. It is safe and effective without severe adverse reactions, which is worthy of clinical promotion.

关 键 词：丹参多酚酸盐注射液 慢性阻塞性肺疾病急性加重 炎性反应 氧化应激 

分 类 号：R285.6[医药卫生—中药学] R286[医药卫生—中医学]