基于三维有限元建模方法分析维医沙疗对兔股骨力学性能的影响  

Influence of sand therapy in Uyghur medicine on mechanical properties of rabbits' femur based on three-dimensional finite element modeling

作　　者：李艳娜[1] 居来提.买提肉孜 尼加提.外力 黄少君[1] 迪丽娜.马合木提 木合塔尔.克力木 张锐[2] 

机构地区：[1]新疆大学机械工程学院,新疆维吾尔自治区乌鲁木齐市830047 [2]新疆医科大学第六附属医院影像中心CT室,新疆维吾尔自治区乌鲁木齐市830054

出　　处：《中国组织工程研究》2016年第27期3957-3962,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(81160542)~~

摘　　要：背景:以现代设计方法与数值仿真为基础的研究方法来探究维医埋沙疗法的作用机制成为了可能。目的:探究一种基于CT值的非均匀各向同性的骨生物有限元建模方法,并观察维医沙疗对兔股骨力学性能的影响。方法:利用木瓜蛋白酶建立8只新西兰成年大白兔右后股骨的骨性关节炎模型,并将其分为沙疗组和对照组。沙疗组进行维医埋沙治疗后,利用CT扫描所有兔股骨模型,将断层影像数据导入MIMICS软件,生成股骨3D模型,对其进行体网格划分,并赋予材料属性,然后在Ansys中进行三点弯曲模拟并求解;同时,对所有兔股骨模型进行体外三点弯曲试验,得到相应的挠度与最大应力值。最后,将基于三维有限元建模方法所得的结果与实验所得的结果进行对比分析。结果与结论:(1)利用兔股骨三维有限元模型进行三点弯曲模拟分析所得到的挠度、最大应力跟试验中所得到的数据都有较好的相关性。(2)结果说明有限元建模方法比较符合骨的结构与材料属性,可用于进行骨骼受力和变形分析。BACKGROUND： On the basis of modern design method and numerical simulation, studies can explore the action mechanisms of sand therapy in Uyghur medicine. OBJECTIVE： To explore a kind of non-homogeneous and isotropic biological bone finite element modeling method based on CT value, and to study the influence of sand therapy in Uyghur medicine on the mechanical properties of rabbits＇ femur. METHODS： Eight adult New Zealand white rabbits were used to establish osteoarthritis models of right posterior femur with papain. These rabbits were divided into sand therapy group and control group. In the sand therapy group, after treatment with sand therapy in Uyghur medicine, rabbit femoral models were scanned with CT. The fault image data were imported into MIMICS software. 3D model of femur was generated. The meshing was done. The material properties were given. Three-point bending in the Ansys was simulated and solved. Simultaneously, the isolated three point bending tests were performed in all rabbit models. The corresponding deflection and the maximum stress values were obtained. Finally, the results obtained from the three-dimensional finite element modeling method were compared with the results obtained from the experiments. RESULTS AND CONCLUSION：（1） The deflection and the maximum stress obtained by the three-point bending simulation analysis with the three-dimensional finite element model of the rabbits＇ femur were well correlated with the data obtained from the experiments.（2） These results indicate that the finite element modeling method is consistent with the structural and material properties of bone, which can be used to analyze the stress and deformation of bones.

关 键 词：有限元分析 股骨 骨关节炎 组织工程 实验动物 骨软骨损伤与修复动物模型 CT值 MIMICS 沙疗 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]