基于气动控制三维打印蔗糖支架的工艺参数  

Three-dimensional printing of a sucrose scaffold based on pneumatic control: relevant technological parameters

作　　者：赵小波[1] 孙开渝 刘翀[1] 

机构地区：[1]杭州电子科技大学生物医学工程与仪器研究所,浙江省杭州市310018

出　　处：《中国组织工程研究》2016年第25期3778-3784,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:蔗糖材料是较为理想的辅助支撑和填充模具材料,很适合在3D打印医疗领域推广应用,目前国内外已有了很多将蔗糖作为打印材料的研究,但制备的支架在精度和孔隙率方面还存在一定的问题。目的:通过3D打印技术研究蔗糖支架的工艺参数。方法:从物理和化学性质出发,研究蔗糖黏度和热分解随温度的变化情况,基于气动控制的F DM技术,通过研究成型过程中的温度气压匹配、分层设定、速度气压匹配等工艺参数,得到良好成型的蔗糖支架,并对其进行显微镜观察标定,采用液体浸泡法(无水乙醇)测定支架的孔隙率。结果与结论:蔗糖材料在温度达到180℃就会发生完全熔融,流动性最大,超过195℃就会发生焦糖反应;它的黏度随着温度的升高而变小。基于气动控制的三维打印机对蔗糖支架进行成型的最佳工艺参数为170℃-0.2 MPa-12 mm/s(温度-气压-打印速度)。对于良好成型的蔗糖支架,其线宽达到了700μm,平均孔隙率达到了81.893%。BACKGROUND： The sucrose is an ideal material for auxiliary support and mold fil ing that is suitable for application in the medical field with three-dimensional （3D） printing. In China, there are many studies about the 3D printing with sucrose, but the accuracy and porosity of the stent are stil unclear. OBJECTIVE： To explore the technological parameters of the sucrose scaffold by 3D printing technology. METHODS： From the perspective of physical and chemical properties, the sucrose viscosity and thermal decomposition with the change of temperature were analyzed. Based on the pneumatic controlled FDM technology, the mature sucrose scaffold was obtained by researching the match of temperature and pressure, layer setting, as wel as the match of speed and pressure. Then the scaffold was demarcated with microscope, and the porosity was measured by immersion in absolute ethyl alcohol. RESULTS AND CONCLUSION： The sucrose was completely melted at 180 oC, with the biggest liquidity. When the temperature was over 195 oC, the caramel reaction occurred. As the temperature increased, the sucrose viscosity decreased. The optimal molding parameters of the sucrose scaffold with pneumatic control-based 3D printing were 170 oC-0.2 MPa-12 mm/s （temperature-pressure-printing speed）. The line width and mean porosity of the wel -shaped sucrose scaffold were 700 μm and 81.893%, respectively.

关 键 词：生物材料 材料相容性 蔗糖 快速成型技术 气压 工艺参数 孔隙率 

分 类 号：R318[医药卫生—生物医学工程]