Th17细胞及白细胞介素17A、17F对特应性皮炎患者病情的影响  

Effects of Th17,IL-17A and IL-17F on Patient's Condition of Atopic Dermatitis

作　　者：任小丽[1] 苏湘川[1] 石青青[1] 胡雅玉[1] 陈祥恩[1] 陈健[1] 

机构地区：[1]浙江省台州市立医院,台州318000

出　　处：《中国中西医结合皮肤性病学杂志》2016年第3期163-165,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的研究不同严重程度特应性皮炎患者Th17细胞及白细胞介素(IL)-17A、IL-17F的变化,探讨其在特应性皮炎发病中的作用。方法采用流式细胞术检测不同严重程度特应性皮炎患者外周血Th17细胞的比例,采用ELISA测定培养上清液中IL-17A、IL-17F表达水平,以健康成人作为对照。结果轻度AD患者与正常人比较,外周血Th17细胞比例、IL-17A水平增高(P<0.05);中度AD患者与正常人比较,外周血Th17细胞比例及IL-17A水平明显增高(P<0.01);重度AD患者与正常对照组比较,IL-17F水平增高(P<0.05);中度AD患者与轻度AD患者比较,外周血Th17细胞比例及IL-17A水平增高(P<0.05);重度AD患者与中度AD患者比较,外周血Th17细胞比例及IL-17A水平增高(P<0.05)。结论 Th17细胞及IL-17A、IL-17F可能在AD的发生及发展过程中发挥重要作用。Objective In order to investigate the variations of Th17, IL-17A and IL-17F in peripheral blood of the patients with different severity atopic dermatitis （AD） and explore their significances. Methods The percentage of Thl7 cells in peripheral blood of patients with AD were determined by flow cytometry, the levels of IL-17A, IL-17F were detected by ELISA, meanwhile, in healthy adults as controls. Results The percentage of Th17 ceils and the level of IL-17A were increased in patients with the mild AD in comparison with healthy controls （P〈0.05）. The percentage of Th17 cells and the level of IL-17A were significantly higher in patients with the moderate AD than those of healthy controls （P〈0.01）. The level of IL-17F significantly increased in patients with the severe AD in comparison with in healthy controls （P〈0.05）. The percentage of Tb17 cells and the level of IL-17A were higher in patients with the moderate AD than the mild AD （P〈0.05）. The percentage of Th 17 cells and the level of IL-17A were higher in patients with the severe AD in comparison with that the moderate AD （P〈0.05）. Conclusion The Th17 cell, IL-17A and IL-17F may play an important role in the onset, development of patients with AD.

关 键 词：特应性皮炎 TH17细胞 白细胞介素-17A 白细胞介素-17F 

分 类 号：R392.12[医药卫生—免疫学]