胱抑素C及同型半胱氨酸与冠心病病变程度相关性研究  

作　　者：熊波[1] 蔡琳[1] 陈应忠[1] 周名纲[1] 丁寻实[1] 夏茏[1] 

机构地区：[1]成都市第三人民医院心血管内科,成都610031

出　　处：《北方药学》2016年第7期135-136,共2页Journal of North Pharmacy

摘　　要：目的：观察不同病变程度的冠心病患者血浆胱抑素C（Cyst C）和同型半胱氨酸（HCY）水平,研究Cyst C及HCY水平与冠脉狭窄病变的临床关系。方法：选取2015年9月～2016年2月我院心内科收治的冠心病患者134例。根据冠脉造影结果分为单支病变组45例、双支病变组40例和三支病变组49例。根据冠状动脉Gensini评分结果分为轻度狭窄组44例、中度狭窄组46例和重度狭窄组44例。同时选择疑似冠心病患者42例为对照组。分别用ELISA法和高效液相色谱法（High Performance Liquid Chromatography）检测各组受试者血浆中的Cyst C和HCY浓度,并应用Pearson进行分析。结果：随着冠脉病变支数的增加和病变狭窄程度的加重,患者的血浆Csyt C和HCY水平均增高（P〈0.05）。三支病变组、双支病变组、单支病变组之间血浆Csyt C和HCY水平存在差异（P〈0.05）;重度狭窄组、中度狭窄组、轻度狭窄组之间血浆Csyt C和HCY水平同样存在差异（P〈0.05）。患者的血浆Cyst C和HCY水平均与冠脉Gensini积分呈正相关（r=0.514,0.476,P〈0.01）,血浆Cyst C与HCY水平呈显著性正相关（r=0.743,P〈0.01）。结论：冠心病患者血浆Cyst C和HCY水平升高,且随着冠脉病变支数的增加及病变狭窄程度的加重而逐渐增高,同时与冠状动脉Gensini评分正相关。因此临床上联合检测患者血浆Cyst C及HCY水平对于冠状动脉狭窄病变程度有一定的初步预测价值。Objective：To observe the plasmatic cystatin C （Cyst C） and homocysteine （HCY） levels of coronary artery disease（CHD） patients with different lesion extent,and explore the clinical predictive value of Cyst C and HCY on CHD lesions.Methods： 134 patients in the department of Cardiology from September 2015 to February 2016 were selected.According to the results of coronary angiography, they were divided into single-vessellesion group （45 cases）,double vessellesion group （40 cases）,three-vessellesion group （49 cases）. According to the results of coronary Gensini score,they were divided into mild stenosis group （44 cases）,moderate stenosis group （46 cases） ,severe stenosis group（44 cases）.42 CHD suspected cases were enrolled as the control group.The plasmatic cystatin C （Cyst C） and homocysteine （HCY） levels were measured by ELISA and HPLC,and their correlation was analyzed by Pearson.Results：The plasmatic Cyst C and HCY level of single-vessel lesion group, double-vessel lesion group and three-vessel lesion group were higher than the control group （P〈0.05）. three-vessel lesion group were higher than the two-vessel lesion group and single vessel lesion group （P〈O.05）, two-vessel lesion group was higher than the single vessel lesion group （P〈0.05）.The plasmatic Cyst C and HCY level of mild stenosis group, moderate stenosis group and severe steuosis group were higher than the control group （P〈0.05）. severe stenosis group were higher than mild stenosis group and moderate stenosis group （P〈0.05）, moderate stenosis group was higher than mild stenosis （P〈 0.05 ）.the plasmatic cystatin C （Cyst C ） and homocysteine （HCY） levels were positively correlated with coronary Gensini score （r = 0.514, 0.476, P〈0.01 ）, plasma Cyst C and HCY levels were positively correlated （r = 0.743, P〈0.01）.Conclusions：Plasmatic Cyst C and HCY levels in patients with coronary heart disease increased significantly, they could increase gradually

关 键 词：胱抑素C 同型半胱氨酸 冠心病 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]