电压门控钠通道结构与功能的适应性进化  

The Adaptive Structural and Functional Evolution of Voltagegated Sodium Channels

作　　者：陈香香[1] 刘霞[1] 白占涛[1] 

机构地区：[1]延安大学生命科学学院多肽资源药物研究中心陕西省区域生物资源保育利用工程技术研究中心,中国陕西延安716000

出　　处：《生命科学研究》2016年第3期255-259,共5页Life Science Research

基　　金：国家自然科学基金资助项目(81470051;81171038);陕西省科技厅项目(2010JM4041;2011K17-01-04;2012K01-12);陕西省教育厅项目(12JS121;15JF034);延安大学陕西省高水平大学建设项目(2012SXTS06);延安市科技创新团队和榆林市科技计划项目(2015CXY-21)

摘　　要：电压门控钠通道是细胞兴奋性的重要分子基础,在进化演变中远早于神经元。伴随从细菌到脊椎动物的适应性演变,电压门控钠通道逐渐呈现出复杂的结构、功能和亚型多样性,且与诸多人类疾病密切相关。明确电压门控钠通道时空演变的适应性进化,解析电压门控钠通道的功能和结构多样性与人类重大疾病发生机制的相关性,有助于推进电压门控钠通道靶向临床诊疗新策略和新药的发现。Voltage-gated sodium channels, which evolved even earlier than the appearance of neurons, are the molecular basis of cell excitability. During the adaptive evolution from bacteria to vertebrates, the structure, function and subtypes of voltage-gated sodium channels have gradually showed increasing level of di- versity. Nowadays, it has been reported that many voltage-gated sodium channel gene abnormalities can cause human diseases such as epilepsy and pain. Here, spatial-temporal species adaptive evolution, and di-versities of the voltage-gated sodium channels, and their relationship with human diseases are reviewed, aiming at promoting new discoveries of clinical diagnosis, therapy and drugs targeting sodium channels.

关 键 词：电压门控钠通道 亚型多样性 结构进化 功能进化 适应性进化 

分 类 号：Q257[生物学—细胞生物学]