趋化因子CCL11、D-二聚体水平在荨麻疹中的变化及其意义  

Alterations and significances of serum D-dimer and chemokine CCL11 levels in urticaria patients

作　　者：路涛[1] 司梦雅 邹金波[1] 章淑平[1] 陈晶[1] 焦晓阳[3] 

机构地区：[1]汕头大学医学院第一附属医院皮肤科,广东汕头515041 [2]汕头大学医学院第一附属医院检验科,广东汕头515041 [3]汕头大学医学院细胞分子生物教研室,广东汕头515041

出　　处：《中国热带医学》2016年第6期594-596,共3页China Tropical Medicine

基　　金：广东省卫生和计划生育委员会医学科研基金(No.A2015191)

摘　　要：目的探讨荨麻疹患者血清趋化因子CCL11、血浆D-二聚体水平变化及其与疾病发生发展之间的关系。方法选择51例急性荨麻疹（Acute Urticaria,AU）、慢性荨麻疹（Chronic Urticaria,CU）患者,根据病情分为轻、中、重度组,并挑选健康成人作为正常对照组。采用酶联免疫吸附试验检测3组荨麻疹患者以及正常对照组血清CCL11及血浆D-二聚体水平,并分析其与荨麻疹症状评分（Urticaria Activity Score,UAS）的相关性。结果 CCL11在轻度、中度和重度荨麻疹中的水平分别是20.12（15.40-23.76）、23.85（11.70-28.25）、18.84（13.10-39.31）,组间比较差异无统计学意义（P=0.95）。D-二聚体在轻度、中度和重度荨麻疹中的水平分别为935.00（580.00-3 360.00）、2 225.00（850.00-65510.00）、3 865.00（1 235.00-7 820.00）,重度和轻度组间比较差异有统计学意义（P=0.04）,血清CCL11水平与D-二聚体未见显著相关（r=-0.078,P=0.594）。结论趋化因子CCL11、D-二聚体水平在急、慢性荨麻疹均升高,提示两者可能参与疾病发生,且D-二聚体升高提示疾病活动,可作为病情的监测指标。Objective To determine the changes of serum levels of chemokine CCL11 and D-dimer and investigate theirrelationship with the disease progress in the urticaria patients. Methods A total of 51 patients with acute urticaria（AU）orchronic urticaria（CU）admitted in our department were enrolled in the study. They were divided into 3 groups according to theseverity of the disease,that is,mild,moderate,severe groups. Another 25 healthy adults served as normal control group. Serumlevels of CCL11 and D-dimer were measured by ELISA,and the correlation of the levels of CCL11 and D-Dimer with urticariaactivity score（UAS）were analyzed. Results The serum CCL11 level was 18.84（13.10-39.31）,23.85（11.70-28.25）and20.12（15.40-23.76）pg/m L respectively,in the mild,moderate,severe groups,and there was no significant difference amongthe groups（P=0.95）. And the D-dimer level was 3 865.00（1 235.00-7 820.00）,2 225.00（850.00-65 510.00）and 935.00（580.00-3 360.00）μg/L respectively in the 3 groups,and significance difference was found between the mild and severe groups（P=0.04）. There was no significant correlation was seen between the serum levels of CCL11 and D-dimer（ r =0.078,P=0.594）. Conclusion Both chemokines CCL11 and D-dimer are elevated in AU and CU patients,indicating that both of themmay be involved in the occurrence of the disease. What＇s more,elevated D-dimer level suggests the disease activity,and canbe used as monitoring indicator for the disease.

关 键 词：荨麻疹 趋化因子CCL11 D-二聚体 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]