KF/Al_2O_3在C-N偶联反应中的应用研究  

Application Research of KF/Al_2O_3 in C-N Coupling Reaction

作　　者：王凡[1] 张茹[1] 喻敏[1] 

机构地区：[1]南京晓庄学院环境科学学院,江苏南京211171

出　　处：《化工时刊》2016年第5期11-13,31,共4页Chemical Industry Times

基　　金：江苏省高等学校大学生创新创业训练计划(201411460027Y);南京晓庄学院青年专项基金(2012NXY99);江苏省高校自然科学研究面上项目(15KJD150003)

摘　　要：以Cu_2O纳米颗粒作为催化剂,KF/Al_2O_3作为碱,成功实现了N-芳基咪唑类化合物的合成,其结构经1H NMR确证。考察了催化剂、配体、KF的负载量、碱的煅烧温度、溶剂、反应温度、碱的种类等反应条件对偶联反应的影响。实验结果表明,在最佳反应条件:Cu_2O纳米颗粒作为催化剂,KF/Al_2O_3-30%-450℃作为碱,DMF为溶剂,于130℃反应20 h,成功地实现了溴苯与咪唑的偶联,反应的收率达到80.8%。Abstract N - arylimidazoles compounds were synthesized by using cuprous oxide nanoparticles as catalyst, KF/Al2O3 as the base. The structures were confirmed by 1H NMR. The coupling reaction condition, such as catalyst, lig-and, the loading of KF, calcination temperature of the base, solvent, reaction temperature and the type of base were investigated. Under the optimum conditions 1 catalyst, KF/Al2O3 - 30% -450 ℃ as base, mmol bromobenzene, 1.5 mmol imidazole, with 5 mol% Cu2O NPs as DMF as the solvent, at 130℃for 20 h, the yield of the C - N couplin greaction were up to 80.8%.

关 键 词：咪唑KF/Al2O3 N-芳基咪唑偶联反应 

分 类 号：O621.251[理学—有机化学]