抗着丝点抗体在多种疾病中的变化和意义  

Variation and Significance of Anticentromere Antibody(ACA)in Multi-Diseases

作　　者：邢雪梅[1] 李艳琴[1] 沈刚[1] 张军[1] 刘蓉[2] 李毅[3] 李向东[3] 

机构地区：[1] 西安交通大学医学部附属 3201 医院 检验科,陕西汉中,723000 [2] 陕西省疾病预防控制中心慢性病管理科,西安,710054 [3] 西安交通大学医学部附属 3201 医院 肾病科,陕西汉中,723000

出　　处：《现代检验医学杂志》2016年第3期88-91,共4页Journal of Modern Laboratory Medicine

摘　　要：目的研究抗着丝点抗体（anticentromere antibody，ACA）在多种疾病中的表达，为临床诊治提供指导。方法回顾性分析129例 ACA阳性患者的临床资料及实验室检测指标。结果①129例 ACA阳性患者中女性116例，男性13例，女性 ACA的血清滴度高，复合型抗体多见，与男性相比差异有统计学意义（χ2＝6.28，P＝0.01；χ2＝6.85，P＝0.003）。②118例有详细临床资料的患者中自身免疫疾病65例（55.08％），非自身免疫疾病53例（44.92％）。自身免疫疾病多见复合型、高滴度抗体，与非自身免疫疾病比较差异有统计学意义（χ2＝21.97，P＜0.001；χ2＝11.44，P＝0.001）。结论 ACA在自身免疫疾病和非自身免疫疾病中均可见到，临床表现多样，且可引起多器官受累，应引起足够重视。Objective To study the expression of anticentromere antibody （ACA）on multiple diseases to help the clinical diag-nosis and treatment.Methods The clinical and laboratory data of 129 cases with positive ACA were retrospectively ana-lyzed.Results ①116 females and 13 males were found among 129 cases with positive ACA,and serology titer of ACA in fe-male patients was higher than male and more compound antibody were shown in female patients,which was significantly dif-ferent compared with males （χ2=6.28,P=0.01;χ2=6.85,P=0.003）.②Among 118 cases which had detailed clinical in-formation,there were 65 patients suffered from autoimmune diseases （55.08%）and 53 cases suffered from non-autoimmune diseases （44.92%）.Autoimmune disease cases showed more compound and high serology titer,there were significant differ-ence between the two groups （χ2=21.97,P〈0.001;χ2=11.44,P=0.001）.Conclusion Though ACA was rarely found,it was shown in autoimmune and non-autoimmune diseases and can be not too severe or fetal and even lead to multi-organ fail-ure.So it should be taken seriously.

关 键 词：抗着丝点抗体 自身免疫性疾病 

分 类 号：R593.2[医药卫生—内科学] R392.11[医药卫生—临床医学]