血清CA125联合ALDH1检测在子宫内膜异位症诊断和术后随访中的应用  

Serum CA125 and ALDH1 levels for diagnosis and postoperative follow-up of endometriosis

作　　者：刘颂平[1] 殷新明[1] 温坚[1] 

机构地区：[1]江苏大学第四附属医院妇产科,江苏镇江212001

出　　处：《西安交通大学学报（医学版）》2016年第4期578-581,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：江苏省自然科学基金资助项目(No.BK20140502);江苏省"六大人才高峰"资助项目(No.2015-WSW-088);吴阶平医学基金资助项目(No.320.6755.15023)~~

摘　　要：目的 探讨血清糖类抗原125（CA125）、乙醛脱氢酶1（ALDH1）联合检测在子宫内膜异位症（EMs）的诊断及术后随访中的应用价值。方法 研究组选取2011年1月～2013年6月于我院妇科经手术及病理切片证实为EMs的患者105例,对照组选取同期于我院健康体检的育龄期女性100例,采用酶联免疫吸附法（ELISA）检测两组患者血清CA125、ALDH1水平。结果 研究组术前血清CA125、ALDH1均高于对照组（P〈0.05）,Ⅰ、Ⅱ期EMs患者血清ALDH1水平高于对照组（P〈0.05）,但血清CA125水平与对照组比较差异无统计学意义（P〉0.05）。以血清CA125≥35U/mL、ALDH1≥2.0pg/mL为阳性临界值,两者联合诊断的特异度、灵敏度、阳性预测值、阴性预测值分别为87.1%、91.6%、84.6%和89.3%。研究组随访发现术后1个月血清CA125、ALDH1较术前明显下降（P〈0.05）,但仍高于对照组（P〈0.05）,术后6个月血清CA125、ALDH1下降至正常水平,与对照组比较差异无统计学意义（P〉0.05）。术后1年1例复发,术后2年6例复发,复发患者血清ALDH1水平均高于对照组,但血清CA125水平仅2例高于对照组。结论血清CA125、ALDH1联合检测较CA125单独检测能显著提高EMs诊断的敏感性,且血清ALDH1水平在轻度EMs及复发患者中均升高,有望成为早期诊断及监测复发更好的指标。Objective To investigate CA125 and ALDH1 levels in diagnosis and postoperative follow‐up of endometriosis （EMs） .Methods Serum CA125 and ALDH1 levels were tested by enzyme‐linked immunosorbent assay （ELISA） in 105 patients with EMs and 100 healthy subjects who came to our hospital between January 2011 and June 2013 .Results The preoperative serum CA125 and ALDH1 levels of EMs patients were significantly higher than those in the control group （ P〈0 .05） .Serum ALDH1 levels in stages I and II of EMs were significantly higher than those in the control group （P〈0 .05） ,but there was no difference in serum CA125 level between the two groups （ P〉0 .05） .Taking CA125≥35 U/mL and ALDH1≥2 .0 pg/mL as the boundary values ,the specificity , sensitivity ,positive predictive value and negative predictive value of serum CA 125 combined with ALDH1 for diagnosis of EMs were 87 .1% ,91 .6% ,84 .6% and 89 .3% ,respectively .One month after operation ,serum CA125 and ALDH1 levels of EMs patients were decreased significantly （P〈0 .05） ,but they were still higher than those in the control group （ P〈0 .05） .Six months after operation ,their serum CA125 and ALDH1 levels did not differ from those in the control group （P〉0 .05） .Relapse occurred in 1 patient 1 year after treatment and in 6 patients 2 years after treatment ;all these patients had a higher serum ALDH1 level than the control group ,but only 2 of them had a higher serum CA125 level .Conclusion The combined detection of serum CA125 and ALDH1 has a higher sensitivity in diagnosis of EMs .Serum ALDH1 level increases in stages Ⅰ and Ⅱ and recurrent patients and can become a better serum marker for early diagnosis and detection of the recurrence of EMs in patients .

关 键 词：子宫内膜异位症 血清糖类抗原125(CA125) 乙醛脱氢酶1(ALDH1) 

分 类 号：R711.71[医药卫生—妇产科学]