慢性肾功能衰竭患者脑钠肽及超敏C反应蛋白水平与心力衰竭的相关性  

Correlation of Plasma Brain Natriuretic with Heart Failure in Chronic Renal Peptide and High-Sensitivity C Reactive Protein Levels Failure Patients

作　　者：胡明亮 王丽 钟馨[2] 莫怡浩 李莎 曾敏 王丹丹 

机构地区：[1]广东省深圳市龙华新区人民医院肾内科,广东深圳518109 [2]广东省深圳市龙岗中心医院肾内科,广东深圳518109

出　　处：《医学临床研究》2016年第6期1048-1050,共3页Journal of Clinical Research

基　　金：深圳市龙岗区科技发展基金资助课题（编号：YS2011151）

摘　　要：【目的】探讨慢性肾功能衰竭患者血浆脑钠肽（BNP）及超敏c反应蛋白（hs—CRP）水平与心力衰竭的相关性。【方法】收集慢性肾衰竭合并心力衰竭患者（A组），慢性肾衰竭（B组）以及健康体检者（C组）各30例，测定其血浆BNP及hsCRP的水平，同时采用彩色多普勒超声仪测定心脏左室射血分数（LVEF）、左室收缩末期内径（LVESD）、左室舒张末期内径（LVEDD），并行相关性分析。【结果】A组与B组的BNP、hs—CRP水平均显著高于c组，且差异有显著性（P〈0．05），A组的BNP、hs—CRP水平显著高于B组，且差异有显著性（P〈0．05）；A组的LVESD、LVEDD水平显著高于B组和C组，而LVEF水平显著低于B组和C组的，且差异有显著性（P〈0．05）。慢性肾衰竭患者BNP与hs—cRP水平呈正相关，且两者与LVESD、LVEDD水平呈正相关，而与LVEF呈负相关（P〈0．05）。【结论】慢性肾衰竭合并心力衰竭患者BNP以及hs—CRP水平明显升高，检测BNP、hs—CRP水平对患者病情的诊断以及预后判断具有一定的意义。[Objective] To investigate the correlation of plasma brain natriuretic peptide （BNP） and high- sensitivity C-reactive protein （hs CRP） levels with heart failure correlation in chronic renal failure patients. [Methods]Cases were divided into patients with heart failure and chronic renal failure （A group）, patients with chronic renal failure （group B）, and healthy subjects （group C）, with 30 cases in each group. Plasma levels of hs-CRP and BNP were observed of each case, and color Doppler ultrasound measured left ventricular e- jection fraction （LVEF）, left ventricular end systolic diameter （LVESD）, left ventricular end-diastolic diame ter （LVEDD）. The parallel correlatiorts were analyzed. [Results]BNP and hs-CRP levels in groups A and B were higher than in group C; the differences were statistically significant （ P 〈0.05）. In addition, BNP and hs-CRP levels in group A were higher than in group B; the difference was statistically significant （ P 〈0.05）. LVESD and LVEDD levels were significantly higher in group A than in groups B and C, while LVEF level in group A was significantly lower than that in groups B and C （ P 〈0.05）. The detectable levels of BNP and hs- CRP in chronic renal failure patients were positively correlated, and both were positively correlated with LVESD and LVEDD levels. However, they were negatively correlated with LVEF; the differences were statistically significant （ P 〈0.05）. [Conclusion]BNP and hs-CRP levels were significantly increased in chronic renal failure patients with heart failure. Detection of BNP and hs-CRP levels has certain significance in the diagnosis and prognosis of the disease in patients.

关 键 词：肾功能衰竭 慢性 脑啡肽类 C反应蛋白质 心力衰竭 

分 类 号：R692.5[医药卫生—泌尿科学]