幽门螺杆菌感染与慢性荨麻疹发病的关系分析  

Pathogenesis Analysis of Chronic Urticaria Infected by Helicobacter Pylori

作　　者：杨静 孙兆伟[3] 石钢 

机构地区：[1]重庆市红十字会医院(江北区人民医院)皮肤科,重庆400020 [2]重庆市红十字会医院(江北区人民医院)消化内科,重庆400020 [3]北京市房山区第一医院皮肤科,北京102400

出　　处：《医学临床研究》2016年第6期1138-1140,1143,共4页Journal of Clinical Research

摘　　要：【目的】探讨幽门螺杆菌（Hp）感染与慢性荨麻疹发病的关系，分析抗Hp治疗对慢性荨麻疹临床疗效影响。【方法】选择2013年1月至2015年6月本院收治的102例慢性荨麻疹患者为研究对象，选取医院同期体检健康者102例作为对照组。观察组经13C呼气试验检测将HP阳性患者随机分为A组（45例）和B组（44例），13例Hp阴性患者作为C组。A、B、C组均给予依巴斯汀片10毫克／次，1次／日，连续服用3个月，A组联合抗HP四联疗法，观察各组疗效及治疗后复发情况。【结果】慢性荨麻疹患者Hp阳性率87．25％显著高于健康者HP阳性率30．39％（x2=68．0810，P〈0．05）；经治疗后，A、C组患者总有效率分别为91．11％（41／45）、84．62％（12／13）显著高于B组的43．18％（19／44）（x2=23．2653、9．7624，P〈0．05）；治疗后A组13C呼气检测值显著低于B组（P〈0．05），A组治疗前后Hp感染情况明显好转（P〈0．05），B组治疗前后HP感染无显著变化；A组总复发率显著低于B组（P〈0．05），A组总复发率低于C组，但无统计学差畀（P〉0．05）；治疗前A、B组IgE水平均显著高于C组（P〈0．05）。【结论】慢性荨麻疹发病可能与Hp感染相关，Hp阳性患者联合抗Hp四联疗法有利于治疗慢性荨麻疹。[Objective] To investigate the relationship between helicobacter pylori （Hp） infection and the pathogenesis of chronic urticaria and analyze the impact of anti-Hp therapy on the clinical efficacy. KMethodsl A total of 102 patients with chronic urticaria from September 2014 to July 2015 in the hospital were selected as study subjects. One hundred and two health examinees in the hospital at the same period were selected as control group. The Hp positive patients were divided into group A （45 cases） and group B （44 patients） according to 13C breath test, 13 cases of Hp-negative patients were selected as group C. All of patients were given ebastine tablets 10mg / times, once/ day, for a continuousness of three months, while patients in the Group A were given anti-Hp quadruple therapy. The efficacy and relapse of each group after treatment were observed. [Results]The Hp positive rate of patients with chronic urticaria was 87.25%, which was significantly higher than that in the control group 30.39% （x2 =68.0810, P 〈0.05）. After treatment, the total efficiency of A, C group was 91.11%, 84.62% respectively, which was significantly higher than that in the Group B 43.18% （x2 =23.2653.9.7624, P 〈0.05）. After treatment the 13C breathe test values in the Group A was significantly lower than that in the Group B （ P 〈0.05）, Hp infection in the Group A was significantly improved before and after treatment （ P〈0.05）, while Hp infection in the Group B had no significant change. The overall recurrence rate in the Group A was significantly lower than that in group B （ P 〈0.05）. The total recurrence rate of the Group A was lower than that of the Group C, but there was no significant difference （ P 〉0.05） Before treatment, the levels of A and IgE in the Group B were significantly higher than those in the Group C （ P 〈0.05）.[Conclusion]The incidence of chronic urticaria may be related to Hp infection. Anti Hp quadruple therapy for patients with positive Hp is beneficial to the tre

关 键 词：螺杆菌 幽门 螺杆菌感染 荨麻疹 慢性病 复发 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]