盐酸羟考酮注射液复合丙泊酚麻醉用于内镜下食管胃底静脉曲张套扎术的疗效和安全性  

Comparison of analgesia effect between oxycodone + propofol and sufentanil + propofol in patients undergoing esophageal gastric varices ligation operation

作　　者：刘玉明[1] 姚志雄[1] 叶孝银 吴冰冰[1] 

机构地区：[1]福州市传染病医院福建医科大学孟超肝胆医院麻醉科,福建福州350025

出　　处：《岭南现代临床外科》2016年第3期314-316,共3页Lingnan Modern Clinics in Surgery

摘　　要：目的评价盐酸羟考酮注射液与舒芬太尼复合丙泊酚用于肝硬化食管胃底静脉曲张患者内镜下套扎治疗的效果及安全性。方法 48例肝硬化食管胃底静脉曲张拟行内镜下套扎治疗的患者,分为羟考酮注射液复合丙泊酚组(A组)和舒芬太尼复合丙泊酚组(B组),每组24例。A组静脉注射羟考酮注射液0.1 mg/kg,丙泊酚2 mg/kg诱导,后以丙泊酚4~7 mg·kg^(-1)·h^(-1)维持;B组注射舒芬太尼1μg/kg,丙泊酚2 mg/kg诱导,后以丙泊酚4~7 mg·kg^(-1)·h^(-1)维持。观察两组患者不同时间点的平均动脉压(MAP)、心率(HR)、呼吸频率(RR)、血氧饱和度(SpO_2)和麻醉深度(BIS);记录呛咳、体动次数、丙泊酚总用量、呼吸抑制及术后30 min疼痛评分。结果两组各时间段MAP、HR、RR及SpO_2差异无统计学意义(P>0.05),A组发生呛咳、体动、呼吸抑制发生的总例数少于B组(P<0.05),同时,A组中丙泊酚用量及术后30 min疼痛评分的概率明显低于B组。结论盐酸羟考酮注射液复合丙泊酚麻醉下行内镜食管胃底曲张静脉套扎,对循环和呼吸系统影响小,不良反应较少,镇痛作用持久,麻醉效果好。Objective To investigate the efficacy and safety of oxycodone hydrochloride injection combined with propofol or sufentanil in patients underwent esophageal gastric varices （EGV） ligation operation. Methods Forty-eight patients with EGV were divided into two groups （n=24 each）, oxycodone hydrochloride injection group （group A） and sufentanil injection group （group B）. Patients in group A were administrated in vein with 0.1 mg/kg of oxycodone, induced with propofol 2 mg/kg and maintained with 4-7 mg^-1. kg-1 .h-1 propofol. Patients in group B were administrated in vein with 1 μg/kg of sufentanil, induced with 2 mg/kg of propofol and maintained with 4-7 mg^-1. kg^- 1 . h^- 1 of propofol. MAP, HR, RR, SPO2, BLS were continuously monitored. Cough, respiratory depression, total dosage of propofol and postoperative 30 min pain score were recorded. Results There were no significant differences in MAP, HR, RR, SPO2 and BLS between two groups （all P values were more than 0.05）. The rates of adverse effects such as cough, body movement, respiratory depression, total dosage of propofol and postoperative 30 min pain score in group A were significantly lower than that of group B （P〈0.05）. Conclusion In the present study, xycodone hydrochloride injection was a safer and more effective treatment in patient underwent EGV ligation operation.

关 键 词：盐酸羟考酮注射液 舒芬太尼注射液 内镜 食管胃底静脉曲张 

分 类 号：R614[医药卫生—麻醉学]