泛素-蛋白酶体抑制剂对血管平滑肌细胞凋亡和动脉粥样硬化的影响  

Effects of ubiquitin-proteasome inhibitor on apoptosis of vascular smooth muscle cells and atherosclerosis

作　　者：王莹[1] 孙瑞红[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,哈尔滨150001

出　　处：《实用药物与临床》2016年第6期768-772,共5页Practical Pharmacy and Clinical Remedies

基　　金：2013年黑龙江省自然科学基金资助项目(H201-306)

摘　　要：泛素-蛋白酶体系统(Ubiquitin proteasome system,UPS)是真核细胞内蛋白质降解的核心途径,对细胞周期、炎症反应、细胞凋亡的调节起十分重要的作用。血管平滑肌细胞(Vascular smooth muscle cells,VSM C)作为血管壁的重要细胞成分,其增殖与凋亡的失平衡是决定动脉粥样硬化发生、发展的关键环节。在VSM C中,细胞凋亡与UPS活性密切相关,且UPS对动脉粥样硬化各个阶段有显著的调节作用。泛素-蛋白酶体抑制剂(Ubiquitin-proteasome inhibitors,UPI)通过抑制凋亡相关蛋白的降解,从而调控VSMC的凋亡,影响动脉粥样硬化形成的各个阶段。本文综述了UPI对VSMC凋亡的影响及其在动脉粥样硬化各阶段的调节作用。Ubiquitin-proteasome system（UPS） is the principal degradation route of proteins in eukaryotic cells,thus playing a crucial role in the regulation of cell cycle inflammation and apoptosis.The imbalance between proliferation and apoptosis of vascular smooth muscle cells（VSMC）,an important cellular component of the vessel wall,is a key in occurrence and development of atherosclerosis.VSMC apoptosis has been associated with UPS,and the UPS has a significant regulatory role in the various stages of atherosclerosis.Proteasome inhibitor（UPI） affects all stages of atherosclerosis formation by inhibiting the degradation of apoptosis-related proteins and regulating the apoptosis of VSMC.This paper reviews the effect of UPI on VSMC apoptosis and regulation of the various stages of atherosclerosis.

关 键 词：泛素-蛋白酶体抑制剂 血管平滑肌细胞 凋亡 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]