莪术醇的处方前研究  

Preformulation study of curcumenol

作　　者：马喆[1] 王芳[2] 金鑫 刘宇[2] 

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004 [2]辽宁大学药学院,沈阳110036 [3]丽珠医药集团股份有限公司,珠海519020

出　　处：《国际药学研究杂志》2016年第3期562-565,共4页Journal of International Pharmaceutical Research

摘　　要：目的对中药单体化合物莪术醇进行处方前研究,为制剂研究奠定基础。方法建立莪术醇液相分析方法,对莪术醇平衡溶解度、油水分配系数、稳定性进行研究。结果莪术醇在纯水中平衡溶解度在25℃下为1.93 mg/ml,在37℃下为2.6 mg/ml。莪术醇的Log P为2.2~3.0。在高温和光照条件下,莪术醇均不稳定。p H对莪术醇溶液稳定性影响较小。结论建立的分析方法准确可靠。莪术醇微溶于水,亲脂性强,可通过增溶技术或制成纳米制剂来提高其生物利用度。莪术醇应阴凉处保存,避光操作。Objective To study the physical-chemical parameters of curcumenol so as to design its optimal preparations.Methods An HPLC method was established to determine the content of curcumenol. Based on the method,the equilibrium solubility,oil/water partition coefficient and stability of curcumenol were investigated. Results The equilibrium solubility in the pure water was1.93 mg/ml（25 ℃）and 2.6 mg/ml（37℃）,respectively. The oil/water partition coefficient was in the range of 2.2-3.0. Curcumenol solution was unstable at high temperature under light conditions,while p H value showed little effect. Conclusion The analytical method is accurate and reliable. The solubility of curcumenol can be described as strong lipotropic and slightly soluble in water. Nanoformulation and solubilization technologies could improve its bioavailability significantly. Curcumenol should be stored and operated in a dark and cool place.

关 键 词：莪术醇 平衡溶解度 油水分配系数 稳定性 

分 类 号：R283.6[医药卫生—中药学]