老年原发性高血压晨峰患者ACE基因多态性与血管紧张素Ⅱ相关性研究  

Correlational Study of ACE Gene Polymorphisms with Angiotensin Ⅱ in Essential Elderly Hypertensive Patients with Morning Blood Pressure Surge

作　　者：黄红[1] 李燕[1] 全胜麟[1] 张彤[1] 全晶[1] 周燕[1] 

机构地区：[1]云南省第一人民医院内干科,云南昆明650032

出　　处：《昆明理工大学学报（自然科学版）》2016年第3期105-108,共4页Journal of Kunming University of Science and Technology(Natural Science)

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项(2013FB202);2013年度云南省教育厅科学研究基金项目(2013C211);云南省卫生和计划生育委员会内设研究机构科研项目(2016NS201)

摘　　要：探讨老年高血压患者血压晨峰现象产生机制.选择150例老年原发性高血压患者根据24h动态血压结果,分为晨峰组和非晨峰组,检测并比较晨峰组与非晨峰组ACE基因多态性及血浆血管紧张素II(Ang II)活性的差异.研究结果显示:晨峰组与非晨峰组比较,DD基因型在晨峰组较非晨峰组升高,同时Ang II活性在晨峰组DD型中较非晨峰组DD型升高,差异有统计学意义(P<0.05).血压晨峰的发生可能与ACE基因DD型有关,通过调节Ang II而形成.The study aims to explore the generation mechanism of morning blood pressure surge（MBPS） in elderly patients with essential hypertension. According to 24 hour ambulatory blood pressure （ABP） monitoring results, 150 elderly patients with essential hypertension are divided into MBPS group and Non -MBPS group. Researchers detect and compare the differences of the ACE gene polymorphism and the plasma angiotensin Ⅱ（AngⅡ） activity in both groups. The results show ： By comparison, the level of DD genotype in MBPS group is higher than the level in Non - MBPS group. And there is a greater increase of Angll activity in DD genotype in MBPS group than that of Non - MBPS group. These differences are statistically significant （P 〈 0. 05 ）. The occurrence of MBPS may be related to the ACE gene DD genotype through adjustment to the level of plasma AngII.

关 键 词：老年人 原发性高血压 血压晨峰 ACE基因 基因多态性 血管紧张素Ⅱ 

分 类 号：R541.3[医药卫生—心血管疾病]