硫酸氨基葡萄糖联合非甾体抗炎药在轻中度膝骨关节炎中的作用  

Effect of glucosamine sulfate combined with non-steroidal anti-inflammatory drugs in light and moderate knee osteoarthritis

作　　者：卢宏伟[1] 罗飞[1] 侯天勇[1] 周强[1] 何清义[1] 

机构地区：[1]第三军医大学附属西南医院全军矫形外科中心,重庆400038

出　　处：《中国医药导报》2016年第17期137-139,148,共4页China Medical Herald

摘　　要：目的研究硫酸氨基葡萄糖联合非甾体抗炎药（NSAIDs）治疗轻中度膝骨关节炎的效果。方法选取2013年4月-2014年4月在第三军医大学附属西南医院诊治的128例轻中度膝骨关节炎患者作为研究对象,将其随机分为A组和B组,各64例。A组采用硫酸氨基葡萄糖联合外用NSAIDs治疗,B组单独外用NSAIDs治疗。分别采用麦克马斯特大学西安大略关节炎指数（WOMAC）、视觉模拟评分（VAS）以及总改善率作为疗效评估指标,进而比较两组治疗方案的效果。结果纳入的128例患者中,10例失去随访,1例局部出现皮疹,其余完成12周治疗,最终A组59例,B组58例。治疗8、12周后,A组和B组WOMAC评分均显著低于治疗前,差异均有统计学意义（P〈0.05）。治疗8、12周后A组WOMAC疼痛、关节功能评分、总分及VAS评分均明显低于B组,差异均有高度统计学意义（P〈0.01）。停药后2周A组WOMAC、VAS评分明显低于B组,差异均有高度统计学意义（P〈0.01）。停药后2周A组总改善率（86.2%）显著高于B组（33.9%）,差异有统计学意义（P〈0.05）。结论硫酸氨基葡萄糖联合外用NSAIDs治疗轻中度膝骨关节炎效果良好,是较好的治疗选择。Objective To study the effect of glucosamine sulfate combined with non-steroidal anti-inflammatory drugs（NSAIDs） in the treatment of light and moderate knee osteoarthritis. Methods One hundred and twenty eight cases of patients with light and moderate knee osteoarthritis admitted to Southwest Hospital Affiliated to Third Military Medical University from April 2013 to April 2014 were selected as research objects, and they were randomly divided into group A and group B, with 64 cases in each group. Group A was administered with glucosamine sulfate and topical NSAIDs,while group B was given single topical NSAIDs. The western Ontario Mc Master universities arthritis index（WOMAC）,visual analog scale（VAS） and total improvement rate were chosen as effect evaluation criterions, so as to evaluate the efficacy of two different therapeutic schedules. Results Among the 128 cases who were included, 10 cases lost followup, one case showed local skin rash, the other cases completed treatment for 12 weeks, finally there were 59 cases in group A and 58 cases in group B. After treatment for 8, 12 weeks, the scores of WOMAC in group A and group B were all decreased significantly compared with those before treatment, the differences were all statistically significant（P〈0.05）. After treatment for 8, 12 weeks, the scores of pain, joint function and total scores in WOMAC and VAS in group A were all lower than those of group B, the differences were all highly statistically significant（P〈0.01）. Two weeks after drug discontinuation, the scores of WOMAC and VAS in group A were all lower than those of group B, the differences were all highly statistically significant（P〈0.01）. Two weeks after drug discontinuation, the total improvement rate in group A（86.2%） was higher than that of group B（33.9%）, the difference was statistically significant（P〈0.05）.Conclusion Glucosamine sulfate combined with topical NSAIDs in the treatment of light and moderate knee osteoarthritis has a good effect, which is a be

关 键 词：硫酸氨基葡萄糖 非甾体抗炎药 膝骨关节炎 

分 类 号：R684.3[医药卫生—骨科学]